Determination of the median lethal dose of indoxacarb pesticide in Wistar rat
Indoxacarb is a novel organophosphate substitute and is considered a “lower risk” pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked to substantial health problems. This study was carried out to investigate the acute oral toxicity and histopathological c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2023-06-01
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| Series: | Journal of Veterinary and Animal Sciences |
| Subjects: | |
| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_ry1cje.pdf?t=ry1cje |
| Summary: | Indoxacarb is a novel organophosphate substitute and is considered a “lower risk”
pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked
to substantial health problems. This study was carried out to investigate the acute oral toxicity and
histopathological changes of indoxacarb in female Wistar albino rats. The acute oral toxicity of
indoxacarb was performed as per the OECD guidelines No. 425, (Acute Oral Toxicity - Up-anddown
procedure). The LD50 of indoxacarb was estimated using AOT425StatPgm (version: 1.0)
statistical program and found to be 1098 mg/kg. Hence the pesticide is categorized as Type II class
of pesticide according to the WHO standards. All the animals dosed at 2000 mg/kg died within 12
h exhibiting clinical signs of intermittent episodes of tremors, incoordination, respiratory distress
and open-mouth breathing. Histopathological examination of indoxacarb treated rats at 2000mg/
kg degeneration of hepatocytes and necrosis in haematoxylin and eosin staining. |
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| ISSN: | 0971-0701 2582-0605 |