Determination of the median lethal dose of indoxacarb pesticide in Wistar rat
Indoxacarb is a novel organophosphate substitute and is considered a “lower risk” pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked to substantial health problems. This study was carried out to investigate the acute oral toxicity and histopathological c...
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| Format: | Article |
| Language: | English |
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Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2023-06-01
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| Series: | Journal of Veterinary and Animal Sciences |
| Subjects: | |
| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_ry1cje.pdf?t=ry1cje |
| _version_ | 1797775652120690688 |
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| author | Archana Raj N. Suresh Nair A.R. Nisha S. Sujith C. Divya R. Shankar |
| author_facet | Archana Raj N. Suresh Nair A.R. Nisha S. Sujith C. Divya R. Shankar |
| author_sort | Archana Raj |
| collection | DOAJ |
| description | Indoxacarb is a novel organophosphate substitute and is considered a “lower risk”
pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked
to substantial health problems. This study was carried out to investigate the acute oral toxicity and
histopathological changes of indoxacarb in female Wistar albino rats. The acute oral toxicity of
indoxacarb was performed as per the OECD guidelines No. 425, (Acute Oral Toxicity - Up-anddown
procedure). The LD50 of indoxacarb was estimated using AOT425StatPgm (version: 1.0)
statistical program and found to be 1098 mg/kg. Hence the pesticide is categorized as Type II class
of pesticide according to the WHO standards. All the animals dosed at 2000 mg/kg died within 12
h exhibiting clinical signs of intermittent episodes of tremors, incoordination, respiratory distress
and open-mouth breathing. Histopathological examination of indoxacarb treated rats at 2000mg/
kg degeneration of hepatocytes and necrosis in haematoxylin and eosin staining. |
| first_indexed | 2024-03-12T22:38:44Z |
| format | Article |
| id | doaj.art-c16bf6be6ed743a98c300db7c3b508b5 |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-03-12T22:38:44Z |
| publishDate | 2023-06-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-c16bf6be6ed743a98c300db7c3b508b52023-07-21T10:45:04ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052023-06-0154251051510.51966/jvas.2023.54.2.510-515Determination of the median lethal dose of indoxacarb pesticide in Wistar ratArchana Raj0https://orcid.org/0000-0002-8696-0541N. Suresh Nair1https://orcid.org/0000-0002-2178-150XA.R. Nisha2https://orcid.org/0000-0001-7121-1954S. Sujith3https://orcid.org/0000-0001-5205-2986C. Divya 4R. Shankar5MVSc Scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssociate Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssociate Professor and Head , Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences,Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaMVSc Scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India Indoxacarb is a novel organophosphate substitute and is considered a “lower risk” pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked to substantial health problems. This study was carried out to investigate the acute oral toxicity and histopathological changes of indoxacarb in female Wistar albino rats. The acute oral toxicity of indoxacarb was performed as per the OECD guidelines No. 425, (Acute Oral Toxicity - Up-anddown procedure). The LD50 of indoxacarb was estimated using AOT425StatPgm (version: 1.0) statistical program and found to be 1098 mg/kg. Hence the pesticide is categorized as Type II class of pesticide according to the WHO standards. All the animals dosed at 2000 mg/kg died within 12 h exhibiting clinical signs of intermittent episodes of tremors, incoordination, respiratory distress and open-mouth breathing. Histopathological examination of indoxacarb treated rats at 2000mg/ kg degeneration of hepatocytes and necrosis in haematoxylin and eosin staining.https://jvas.in/public_html/upload/article_file/article_file_ry1cje.pdf?t=ry1cjeindoxacarboral ld50wistar ratsacute oral toxicityhepatotoxicity |
| spellingShingle | Archana Raj N. Suresh Nair A.R. Nisha S. Sujith C. Divya R. Shankar Determination of the median lethal dose of indoxacarb pesticide in Wistar rat Journal of Veterinary and Animal Sciences indoxacarb oral ld50 wistar rats acute oral toxicity hepatotoxicity |
| title | Determination of the median lethal dose of indoxacarb pesticide in Wistar rat |
| title_full | Determination of the median lethal dose of indoxacarb pesticide in Wistar rat |
| title_fullStr | Determination of the median lethal dose of indoxacarb pesticide in Wistar rat |
| title_full_unstemmed | Determination of the median lethal dose of indoxacarb pesticide in Wistar rat |
| title_short | Determination of the median lethal dose of indoxacarb pesticide in Wistar rat |
| title_sort | determination of the median lethal dose of indoxacarb pesticide in wistar rat |
| topic | indoxacarb oral ld50 wistar rats acute oral toxicity hepatotoxicity |
| url | https://jvas.in/public_html/upload/article_file/article_file_ry1cje.pdf?t=ry1cje |
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