The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk
Introduction Cortisol, the hormonal endpoint of Hypothalamic Pituitary Adrenal (HPA) axis, coordinates the body response in front of daily stressful situations. Disturbances in cortisol circadian rhythm have been implicated in the pathophysiology of depression and neurodevelopment lasting consequen...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822002930/type/journal_article |
| _version_ | 1797616602255982592 |
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| author | Á. Castro Quintas M. Daura-Corral E. Eixarch F. Crispi L. De La Fuente Tomas M. Rocavert Barranco A. Miguel Valero L. Marques Feixa H. Palma Gudiel M.P. Garcia-Portilla L. Fañanas |
| author_facet | Á. Castro Quintas M. Daura-Corral E. Eixarch F. Crispi L. De La Fuente Tomas M. Rocavert Barranco A. Miguel Valero L. Marques Feixa H. Palma Gudiel M.P. Garcia-Portilla L. Fañanas |
| author_sort | Á. Castro Quintas |
| collection | DOAJ |
| description |
Introduction
Cortisol, the hormonal endpoint of Hypothalamic Pituitary Adrenal (HPA) axis, coordinates the body response in front of daily stressful situations. Disturbances in cortisol circadian rhythm have been implicated in the pathophysiology of depression and neurodevelopment lasting consequences. Although pregnancy entails a progressively increase in cortisol levels, the consequences of subclinical depression traits during pregnancy in cortisol circadian rhythm remains unclear.
Objectives
To analyze the impact of prenatal subclinical depressive symptomatology in cortisol circadian rhythm through pregnancy and its relevance for postpartum depression risk.
Methods
A cohort of 112 healthy pregnant women (Mean age±SD=32.32±4.37) of the general population was followed throughout their first pregnancy and first two months of postpartum period. Diurnal salivary cortisol curve (four measures) was obtained for every trimester; the Area Under the Curve with respect to the ground (AUCg) and with respect to the increase (AUCi) were used as measures of basal HPA axis functioning. Depressive symptomatology was assessed every pregnancy trimester and postpartum period following EPDS criteria. All the analyses were adjusted for maternal age, weight, ethnicity and socioeconomic status and sample collection’s time.
Results
Prenatal subclinical depressive symptomatology (EPDS>10) was associated with a blunted cortisol rhythm during first trimester (F= 3.913,p=.011) but not during second (F=2.629, p=056) or third trimesters (F=.411,p=.724). Furthermore, a logistic regression model showed a positive association between Prenatal subclinical depressive symptomatology and the risk of postpartum depression (χ2=13.8, p<.001,OR=9.6; 95%CI 2.5–35.5).
Conclusions
Women with subclinical depressive symptomatology in early pregnancy had alterations in cortisol circadian rhythmicity and a higher risk of postpartum depression.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:43:29Z |
| format | Article |
| id | doaj.art-c16d2dad4ba5433ca2baf3f95885d112 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:43:29Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-c16d2dad4ba5433ca2baf3f95885d1122023-11-17T05:08:08ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S102S10310.1192/j.eurpsy.2022.293The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression riskÁ. Castro Quintas0M. Daura-Corral1E. Eixarch2F. Crispi3L. De La Fuente Tomas4M. Rocavert Barranco5A. Miguel Valero6L. Marques Feixa7H. Palma Gudiel8M.P. Garcia-Portilla9L. Fañanas10University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, SpainUniversity of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, SpainMaternitat Hospital Clinic Barcelona, Bcnatal Fetal Medicine Research Center, Barcelona, SpainMaternitat Hospital Clinic Barcelona, Bcnatal Fetal Medicine Research Center, Barcelona, SpainUniversity of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, SpainUniversity of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, SpainUniversity of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, SpainCentre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, SpainCentre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain University of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain Introduction Cortisol, the hormonal endpoint of Hypothalamic Pituitary Adrenal (HPA) axis, coordinates the body response in front of daily stressful situations. Disturbances in cortisol circadian rhythm have been implicated in the pathophysiology of depression and neurodevelopment lasting consequences. Although pregnancy entails a progressively increase in cortisol levels, the consequences of subclinical depression traits during pregnancy in cortisol circadian rhythm remains unclear. Objectives To analyze the impact of prenatal subclinical depressive symptomatology in cortisol circadian rhythm through pregnancy and its relevance for postpartum depression risk. Methods A cohort of 112 healthy pregnant women (Mean age±SD=32.32±4.37) of the general population was followed throughout their first pregnancy and first two months of postpartum period. Diurnal salivary cortisol curve (four measures) was obtained for every trimester; the Area Under the Curve with respect to the ground (AUCg) and with respect to the increase (AUCi) were used as measures of basal HPA axis functioning. Depressive symptomatology was assessed every pregnancy trimester and postpartum period following EPDS criteria. All the analyses were adjusted for maternal age, weight, ethnicity and socioeconomic status and sample collection’s time. Results Prenatal subclinical depressive symptomatology (EPDS>10) was associated with a blunted cortisol rhythm during first trimester (F= 3.913,p=.011) but not during second (F=2.629, p=056) or third trimesters (F=.411,p=.724). Furthermore, a logistic regression model showed a positive association between Prenatal subclinical depressive symptomatology and the risk of postpartum depression (χ2=13.8, p<.001,OR=9.6; 95%CI 2.5–35.5). Conclusions Women with subclinical depressive symptomatology in early pregnancy had alterations in cortisol circadian rhythmicity and a higher risk of postpartum depression. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822002930/type/journal_article |
| spellingShingle | Á. Castro Quintas M. Daura-Corral E. Eixarch F. Crispi L. De La Fuente Tomas M. Rocavert Barranco A. Miguel Valero L. Marques Feixa H. Palma Gudiel M.P. Garcia-Portilla L. Fañanas The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk European Psychiatry |
| title | The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk |
| title_full | The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk |
| title_fullStr | The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk |
| title_full_unstemmed | The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk |
| title_short | The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk |
| title_sort | role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk |
| url | https://www.cambridge.org/core/product/identifier/S0924933822002930/type/journal_article |
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