Fabrication of an Azithromycin Sensor
Azithromycin (AZY) is a well-known top-prioritized antibiotic and is used by humans in strong concentrations. However, the side effects of the AZY antibiotic may cause some serious and significant damage to humans and the environment. Thus, there is a need to develop effective and sensitive sensors...
| المؤلفون الرئيسيون: | , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
MDPI AG
2023-11-01
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| سلاسل: | Biosensors |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.mdpi.com/2079-6374/13/11/986 |
| _version_ | 1827640382295375872 |
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| author | Theophile Niyitanga Mohd Quasim Khan Khursheed Ahmad Rais Ahmad Khan |
| author_facet | Theophile Niyitanga Mohd Quasim Khan Khursheed Ahmad Rais Ahmad Khan |
| author_sort | Theophile Niyitanga |
| collection | DOAJ |
| description | Azithromycin (AZY) is a well-known top-prioritized antibiotic and is used by humans in strong concentrations. However, the side effects of the AZY antibiotic may cause some serious and significant damage to humans and the environment. Thus, there is a need to develop effective and sensitive sensors to monitor accurate concentrations of AZY. In the last decade, electrochemistry-based sensors have received enormous attention from the scientific community because of their high sensitivity, selectivity, cost-effectiveness, fast response, rapid detection response, simple fabrication, and working principle. It is important to mention that electrochemical sensors rely on the properties of electrode modifiers. Hence, the selection of electrode materials is of great significance when designing and developing efficient and robust electrochemical sensors. In this study, we fabricated an AZY sensor by utilizing a molybdenum disulfide/titanium aluminum carbide (MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub>) composite as the electrode material. The MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite was synthesized via a simple sonication process. The synthesized MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite was characterized using a powder X-ray diffraction (XRD) method to examine the phase purity and formation of the MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite. Scanning electron microscopy (SEM) was used to study the surface morphological features of the prepared MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite, whereas energy dispersive X-ray spectroscopy (EDAX) was adopted to determine the elemental composition of the prepared MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite. The glassy carbon (GC) electrode was modified with the prepared MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite and applied as the AZY sensor. The sensing performance of the MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite-modified GC electrode was studied using linear sweep voltammetry. The sensor demonstrated excellent performance when determining AZY and showed a good detection limit of 0.009 µM with a sensitivity of 6.77 µA/µM.cm<sup>2</sup>. |
| first_indexed | 2024-03-09T16:58:55Z |
| format | Article |
| id | doaj.art-c16d2f1344f848f3802e03c9f1c7f15a |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T16:58:55Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-c16d2f1344f848f3802e03c9f1c7f15a2023-11-24T14:32:27ZengMDPI AGBiosensors2079-63742023-11-01131198610.3390/bios13110986Fabrication of an Azithromycin SensorTheophile Niyitanga0Mohd Quasim Khan1Khursheed Ahmad2Rais Ahmad Khan3School of Materials Science and Engineering, Yeungnam University, Gyeongsan 38541, Republic of KoreaDepartment of Chemistry, M.M.D.C, Moradabad, M.J.P. Rohilkhand University, Bareilly 244001, UP, IndiaSchool of Materials Science and Engineering, Yeungnam University, Gyeongsan 38541, Republic of KoreaDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaAzithromycin (AZY) is a well-known top-prioritized antibiotic and is used by humans in strong concentrations. However, the side effects of the AZY antibiotic may cause some serious and significant damage to humans and the environment. Thus, there is a need to develop effective and sensitive sensors to monitor accurate concentrations of AZY. In the last decade, electrochemistry-based sensors have received enormous attention from the scientific community because of their high sensitivity, selectivity, cost-effectiveness, fast response, rapid detection response, simple fabrication, and working principle. It is important to mention that electrochemical sensors rely on the properties of electrode modifiers. Hence, the selection of electrode materials is of great significance when designing and developing efficient and robust electrochemical sensors. In this study, we fabricated an AZY sensor by utilizing a molybdenum disulfide/titanium aluminum carbide (MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub>) composite as the electrode material. The MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite was synthesized via a simple sonication process. The synthesized MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite was characterized using a powder X-ray diffraction (XRD) method to examine the phase purity and formation of the MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite. Scanning electron microscopy (SEM) was used to study the surface morphological features of the prepared MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite, whereas energy dispersive X-ray spectroscopy (EDAX) was adopted to determine the elemental composition of the prepared MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite. The glassy carbon (GC) electrode was modified with the prepared MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite and applied as the AZY sensor. The sensing performance of the MoS<sub>2</sub>@Ti<sub>3</sub>AlC<sub>2</sub> composite-modified GC electrode was studied using linear sweep voltammetry. The sensor demonstrated excellent performance when determining AZY and showed a good detection limit of 0.009 µM with a sensitivity of 6.77 µA/µM.cm<sup>2</sup>.https://www.mdpi.com/2079-6374/13/11/986Ti<sub>3</sub>AlC<sub>2</sub>MoS<sub>2</sub>MAXazithromycinsensors |
| spellingShingle | Theophile Niyitanga Mohd Quasim Khan Khursheed Ahmad Rais Ahmad Khan Fabrication of an Azithromycin Sensor Biosensors Ti<sub>3</sub>AlC<sub>2</sub> MoS<sub>2</sub> MAX azithromycin sensors |
| title | Fabrication of an Azithromycin Sensor |
| title_full | Fabrication of an Azithromycin Sensor |
| title_fullStr | Fabrication of an Azithromycin Sensor |
| title_full_unstemmed | Fabrication of an Azithromycin Sensor |
| title_short | Fabrication of an Azithromycin Sensor |
| title_sort | fabrication of an azithromycin sensor |
| topic | Ti<sub>3</sub>AlC<sub>2</sub> MoS<sub>2</sub> MAX azithromycin sensors |
| url | https://www.mdpi.com/2079-6374/13/11/986 |
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