Proteolysis of CD44 at the cell surface controls a downstream protease network

Proteolysis of CD44 at the cell surface controls a downstream protease network

The cell surface receptor cluster of differentiation 44 (CD44) is the main hyaluronan receptor of the human body. At the cell surface, it can be proteolytically processed by different proteases and was shown to interact with different matrix metalloproteinases. Upon proteolytic processing of CD44 an...

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Bibliographic Details
Main Authors: Birte Wöhner, Wenjia Li, Sven Hey, Alice Drobny, Ludwig Werny, Christoph Becker-Pauly, Ralph Lucius, Friederike Zunke, Stefan Linder, Philipp Arnold
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
shedding
meprin β
ADAM10
MMP14
CD44
tumor spheroid
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1026810/full

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