Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development
Over a half century has passed since the first discovery of spongothymidine and spongouridine. These sponge-derived natural products initiated a chain of events that has resulted in countless lives saved from viral infections and cancer. In addition these humble marine products inspired th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2007-06-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4332 |
| _version_ | 1811320087828758528 |
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| author | Mark T. Hamann Russell Hill Silvio Roggo |
| author_facet | Mark T. Hamann Russell Hill Silvio Roggo |
| author_sort | Mark T. Hamann |
| collection | DOAJ |
| description |
Over a half century has passed since the first discovery of spongothymidine and spongouridine. These sponge-derived natural products initiated a chain of events that has resulted in countless lives saved from viral infections and cancer. In addition these humble marine products inspired
the critical evaluation of marine life for the production of novel chemistry and new drug leads. The resulting natural products chemistry from these efforts is unprecedented in regard to structural complexity and biological activity. The drug leads based on marine natural products have however
created unique challenges in scaleable production and structural optimization to evaluate toxicity and enhance biological activity. In this report we have focused our discussion on the progress toward the development of general methodologies for the production, optimization and development
of rare but promising marine natural product drug leads. Key developments discussed briefly include sourcing, lead optimization, molecular biology and phylogeny, marine microbial culture, and tools for structure assignment.
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| first_indexed | 2024-04-13T12:53:21Z |
| format | Article |
| id | doaj.art-c16e513141c345b897b69d2d6fc42c64 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-13T12:53:21Z |
| publishDate | 2007-06-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-c16e513141c345b897b69d2d6fc42c642022-12-22T02:46:08ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242007-06-0161610.2533/chimia.2007.313Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug DevelopmentMark T. Hamann0Russell Hill1Silvio Roggo2Tel.: 1 662 915 5730, Departments of Pharmacognosy, Pharmacology, Chemistry and Biochemistry and the National Center for the Development of Natural Products (NCNPR), School of Pharmacy, The University of Mississippi, University, MS 38677, USA, Triton BioPharma Oxford, Mississippi, USA, Email: mthamann@olemiss.eduThe Center of Marine Biotechnology, The University of Maryland Biotechnology Institute, Baltimore MD, USA, Triton BioPharma Oxford, Mississippi, USANovartis Institutes for BioMedical Research, Natural Products Unit, Novartis Pharma AG, CH-4002 Basel Over a half century has passed since the first discovery of spongothymidine and spongouridine. These sponge-derived natural products initiated a chain of events that has resulted in countless lives saved from viral infections and cancer. In addition these humble marine products inspired the critical evaluation of marine life for the production of novel chemistry and new drug leads. The resulting natural products chemistry from these efforts is unprecedented in regard to structural complexity and biological activity. The drug leads based on marine natural products have however created unique challenges in scaleable production and structural optimization to evaluate toxicity and enhance biological activity. In this report we have focused our discussion on the progress toward the development of general methodologies for the production, optimization and development of rare but promising marine natural product drug leads. Key developments discussed briefly include sourcing, lead optimization, molecular biology and phylogeny, marine microbial culture, and tools for structure assignment. https://chimia.ch/chimia/article/view/4332AlkaloidsMarine natural productsPeptidesPolyketidesTerpenoids |
| spellingShingle | Mark T. Hamann Russell Hill Silvio Roggo Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development CHIMIA Alkaloids Marine natural products Peptides Polyketides Terpenoids |
| title | Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development |
| title_full | Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development |
| title_fullStr | Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development |
| title_full_unstemmed | Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development |
| title_short | Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development |
| title_sort | marine natural products key advances to the practical application of this resource in drug development |
| topic | Alkaloids Marine natural products Peptides Polyketides Terpenoids |
| url | https://chimia.ch/chimia/article/view/4332 |
| work_keys_str_mv | AT markthamann marinenaturalproductskeyadvancestothepracticalapplicationofthisresourceindrugdevelopment AT russellhill marinenaturalproductskeyadvancestothepracticalapplicationofthisresourceindrugdevelopment AT silvioroggo marinenaturalproductskeyadvancestothepracticalapplicationofthisresourceindrugdevelopment |