The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study
The most effective treatment for recurrent <i>Clostridioides difficile</i> infection (CDI) is faecal microbiota transplantation (FMT); however, the optimal route of administration is thus far unknown. This retrospective cohort study of 343 patients sought to evaluate the efficacy of trea...
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MDPI AG
2022-10-01
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| author | Camilla Kara Svensson Frederik Cold Iben Ribberholt Mike Zangenberg Hengameh Chloé Mirsepasi-Lauridsen Andreas Munk Petersen Morten Helms |
| author_facet | Camilla Kara Svensson Frederik Cold Iben Ribberholt Mike Zangenberg Hengameh Chloé Mirsepasi-Lauridsen Andreas Munk Petersen Morten Helms |
| author_sort | Camilla Kara Svensson |
| collection | DOAJ |
| description | The most effective treatment for recurrent <i>Clostridioides difficile</i> infection (CDI) is faecal microbiota transplantation (FMT); however, the optimal route of administration is thus far unknown. This retrospective cohort study of 343 patients sought to evaluate the efficacy of treatment with FMT capsules, FMT enema, and rectal bacteriotherapy (RBT) during a five-year period. The primary endpoint was clinical resolution from CDI after eight weeks, and secondary endpoints were time to recurrence and death during the follow-up period. The proportion of patients with clinical resolution was 79.9% in the FMT capsule group, 53.3% in the FMT enema group, and 61.8% in the RBT group, corresponding to an adjusted odds ratio of 3.79 (CI: 1.82 to 8.26) in the FMT capsule group compared with FMT enema, and 2.92 (CI: 1.49 to 6.03) compared with RBT. The hazards ratio for recurrence within the first 12 months of follow-up was 0.24 (CI: 0.06 to 0.89) in the FMT capsule group compared with FMT enema, and 0.26 (CI: 0.08 to 0.91) compared with RBT. There was no difference in mortality. In conclusion, FMT capsules were more effective than both FMT enema and RBT as treatment of recurrent CDI and reduced the risk of further recurrences. |
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| last_indexed | 2024-03-09T20:29:27Z |
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| spelling | doaj.art-c1703adafa18467f9c821a6786b2c1902023-11-23T23:28:23ZengMDPI AGCells2073-44092022-10-011120327210.3390/cells11203272The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort StudyCamilla Kara Svensson0Frederik Cold1Iben Ribberholt2Mike Zangenberg3Hengameh Chloé Mirsepasi-Lauridsen4Andreas Munk Petersen5Morten Helms6Department of Infectious Diseases, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkGastro Unit, Medical Division, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkDepartment of Clinical Microbiology, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkGastro Unit, Medical Division, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, DenmarkThe most effective treatment for recurrent <i>Clostridioides difficile</i> infection (CDI) is faecal microbiota transplantation (FMT); however, the optimal route of administration is thus far unknown. This retrospective cohort study of 343 patients sought to evaluate the efficacy of treatment with FMT capsules, FMT enema, and rectal bacteriotherapy (RBT) during a five-year period. The primary endpoint was clinical resolution from CDI after eight weeks, and secondary endpoints were time to recurrence and death during the follow-up period. The proportion of patients with clinical resolution was 79.9% in the FMT capsule group, 53.3% in the FMT enema group, and 61.8% in the RBT group, corresponding to an adjusted odds ratio of 3.79 (CI: 1.82 to 8.26) in the FMT capsule group compared with FMT enema, and 2.92 (CI: 1.49 to 6.03) compared with RBT. The hazards ratio for recurrence within the first 12 months of follow-up was 0.24 (CI: 0.06 to 0.89) in the FMT capsule group compared with FMT enema, and 0.26 (CI: 0.08 to 0.91) compared with RBT. There was no difference in mortality. In conclusion, FMT capsules were more effective than both FMT enema and RBT as treatment of recurrent CDI and reduced the risk of further recurrences.https://www.mdpi.com/2073-4409/11/20/3272<i>Clostridioides difficile</i> infectionCDIfaecal microbiota transplantationFMTrectal bacteriotherapyRBT |
| spellingShingle | Camilla Kara Svensson Frederik Cold Iben Ribberholt Mike Zangenberg Hengameh Chloé Mirsepasi-Lauridsen Andreas Munk Petersen Morten Helms The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study Cells <i>Clostridioides difficile</i> infection CDI faecal microbiota transplantation FMT rectal bacteriotherapy RBT |
| title | The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study |
| title_full | The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study |
| title_fullStr | The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study |
| title_full_unstemmed | The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study |
| title_short | The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study |
| title_sort | efficacy of faecal microbiota transplant and rectal bacteriotherapy in patients with recurrent i clostridioides difficile i infection a retrospective cohort study |
| topic | <i>Clostridioides difficile</i> infection CDI faecal microbiota transplantation FMT rectal bacteriotherapy RBT |
| url | https://www.mdpi.com/2073-4409/11/20/3272 |
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