Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO
Detailed characterization of the permeability and vascular volume of brain tumor vasculature can provide essential insights into tumor physiology. In this study, we evaluated the consistency of measurements in tumor blood volume and examined the feasibility of using ultrasmall superparamagnetic iron...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2019-11-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2019-0091 |
| _version_ | 1828214108895313920 |
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| author | Yu Xiang-Rong Cao Bo-Ling Li Wei Tian Ye Du Zhong-Li |
| author_facet | Yu Xiang-Rong Cao Bo-Ling Li Wei Tian Ye Du Zhong-Li |
| author_sort | Yu Xiang-Rong |
| collection | DOAJ |
| description | Detailed characterization of the permeability and vascular volume of brain tumor vasculature can provide essential insights into tumor physiology. In this study, we evaluated the consistency of measurements in tumor blood volume and examined the feasibility of using ultrasmall superparamagnetic iron oxide (USPIO) versus gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) as contrast agents for MR perfusion imaging of brain gliomas in C6 Rats. Eighteen rats were intracerebrally implanted with C6 glioma cells, randomly divided into two groups and examined by 3.0T perfusion MR imaging with Gd-DTPA and USPIO. Tumor relative cerebral blood volume (rCBV) and relative maximum signal reduction ratio (rSRRmax) were created based on analysis of MR perfusion images. The mean values for rCBV were 2.09 and 1.57 in the USPIO and the Gd-DTPA groups, respectively, and rSRRmax values were 1.92 and 1.02 in the USPIO and the Gd-DTPA groups, respectively, showing signifi cant differences in both rCBV and rSRRmax between the USPIO and the Gd-DTPA groups (P < 0.05). The results showed that early vascular leakage occurred with gadolinium rather than USPIO in perfusion assessment, revealing that USPIO was useful in perfusion MR imaging for the assessment of tumor vasculature. |
| first_indexed | 2024-04-12T14:59:13Z |
| format | Article |
| id | doaj.art-c171dd9685a64de4910cbaf8b4797063 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T14:59:13Z |
| publishDate | 2019-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-c171dd9685a64de4910cbaf8b47970632022-12-22T03:28:07ZengDe GruyterOpen Medicine2391-54632019-11-0114177878410.1515/med-2019-0091med-2019-0091Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIOYu Xiang-Rong0Cao Bo-Ling1Li Wei2Tian Ye3Du Zhong-Li4Department of Radiology, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, ChinaDepartment of Radiology, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, ChinaDepartment of Radiology, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, ChinaDepartment of Radiology, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, ChinaZhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, 519000, ChinaDetailed characterization of the permeability and vascular volume of brain tumor vasculature can provide essential insights into tumor physiology. In this study, we evaluated the consistency of measurements in tumor blood volume and examined the feasibility of using ultrasmall superparamagnetic iron oxide (USPIO) versus gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) as contrast agents for MR perfusion imaging of brain gliomas in C6 Rats. Eighteen rats were intracerebrally implanted with C6 glioma cells, randomly divided into two groups and examined by 3.0T perfusion MR imaging with Gd-DTPA and USPIO. Tumor relative cerebral blood volume (rCBV) and relative maximum signal reduction ratio (rSRRmax) were created based on analysis of MR perfusion images. The mean values for rCBV were 2.09 and 1.57 in the USPIO and the Gd-DTPA groups, respectively, and rSRRmax values were 1.92 and 1.02 in the USPIO and the Gd-DTPA groups, respectively, showing signifi cant differences in both rCBV and rSRRmax between the USPIO and the Gd-DTPA groups (P < 0.05). The results showed that early vascular leakage occurred with gadolinium rather than USPIO in perfusion assessment, revealing that USPIO was useful in perfusion MR imaging for the assessment of tumor vasculature.https://doi.org/10.1515/med-2019-0091perfusion imaginguspiogd-dtparatglioma |
| spellingShingle | Yu Xiang-Rong Cao Bo-Ling Li Wei Tian Ye Du Zhong-Li Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO Open Medicine perfusion imaging uspio gd-dtpa rat glioma |
| title | Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO |
| title_full | Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO |
| title_fullStr | Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO |
| title_full_unstemmed | Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO |
| title_short | Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO |
| title_sort | accuracy of tumor perfusion assessment in rat c6 gliomas model with uspio |
| topic | perfusion imaging uspio gd-dtpa rat glioma |
| url | https://doi.org/10.1515/med-2019-0091 |
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