Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis
Protozoan parasites represent a major threat to health and contribute significantly to morbidity and mortality worldwide, especially in developing countries. This is further compounded by lack of effective vaccines, drug resistance and toxicity associated with current therapies. Multiple protozoans,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01995/full |
| _version_ | 1818308678015516672 |
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| author | Swagata Ghosh Nona Jiang Laura Farr Renay Ngobeni Shannon Moonah |
| author_facet | Swagata Ghosh Nona Jiang Laura Farr Renay Ngobeni Shannon Moonah |
| author_sort | Swagata Ghosh |
| collection | DOAJ |
| description | Protozoan parasites represent a major threat to health and contribute significantly to morbidity and mortality worldwide, especially in developing countries. This is further compounded by lack of effective vaccines, drug resistance and toxicity associated with current therapies. Multiple protozoans, including Plasmodium, Entamoeba, Toxoplasma, and Leishmania produce homologs of the cytokine MIF. These parasite MIF homologs are capable of altering the host immune response during infection, and play a role in immune evasion, invasion and pathogenesis. This minireview outlines well-established and emerging literature on the role of parasite MIF homologs in disease, and their potential as targets for therapeutic and preventive interventions. |
| first_indexed | 2024-12-13T07:18:05Z |
| format | Article |
| id | doaj.art-c172227ddedd4e9ea2360b4d0caea284 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T07:18:05Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c172227ddedd4e9ea2360b4d0caea2842022-12-21T23:55:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-08-011010.3389/fimmu.2019.01995474629Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and PathogenesisSwagata Ghosh0Nona Jiang1Laura Farr2Renay Ngobeni3Shannon Moonah4Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United StatesDepartment of Medicine, Yale University, New Haven, CT, United StatesDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United StatesDepartment of Environmental, Water, and Earth Sciences, Tshwane University of Technology, Pretoria, South AfricaDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United StatesProtozoan parasites represent a major threat to health and contribute significantly to morbidity and mortality worldwide, especially in developing countries. This is further compounded by lack of effective vaccines, drug resistance and toxicity associated with current therapies. Multiple protozoans, including Plasmodium, Entamoeba, Toxoplasma, and Leishmania produce homologs of the cytokine MIF. These parasite MIF homologs are capable of altering the host immune response during infection, and play a role in immune evasion, invasion and pathogenesis. This minireview outlines well-established and emerging literature on the role of parasite MIF homologs in disease, and their potential as targets for therapeutic and preventive interventions.https://www.frontiersin.org/article/10.3389/fimmu.2019.01995/fullMIFcytokineprotozoan parasiteshost-parasite interactionimmune evasionimmunopathology |
| spellingShingle | Swagata Ghosh Nona Jiang Laura Farr Renay Ngobeni Shannon Moonah Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis Frontiers in Immunology MIF cytokine protozoan parasites host-parasite interaction immune evasion immunopathology |
| title | Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis |
| title_full | Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis |
| title_fullStr | Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis |
| title_full_unstemmed | Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis |
| title_short | Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis |
| title_sort | parasite produced mif cytokine role in immune evasion invasion and pathogenesis |
| topic | MIF cytokine protozoan parasites host-parasite interaction immune evasion immunopathology |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01995/full |
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