Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis
Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmolb.2017.00044/full |
| _version_ | 1818081336353619968 |
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| author | Alexander K. W. Elsholz Marlene S. Birk Emmanuelle Charpentier Emmanuelle Charpentier Emmanuelle Charpentier Kürşad Turgay |
| author_facet | Alexander K. W. Elsholz Marlene S. Birk Emmanuelle Charpentier Emmanuelle Charpentier Emmanuelle Charpentier Kürşad Turgay |
| author_sort | Alexander K. W. Elsholz |
| collection | DOAJ |
| description | Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics. |
| first_indexed | 2024-12-10T19:04:35Z |
| format | Article |
| id | doaj.art-c173756ef83446b08a05439882d89953 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-10T19:04:35Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-c173756ef83446b08a05439882d899532022-12-22T01:36:56ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2017-07-01410.3389/fmolb.2017.00044274020Functional Diversity of AAA+ Protease Complexes in Bacillus subtilisAlexander K. W. Elsholz0Marlene S. Birk1Emmanuelle Charpentier2Emmanuelle Charpentier3Emmanuelle Charpentier4Kürşad Turgay5Department of Regulation in Infection Biology, Max Planck Institute for Infection BiologyBerlin, GermanyDepartment of Regulation in Infection Biology, Max Planck Institute for Infection BiologyBerlin, GermanyDepartment of Regulation in Infection Biology, Max Planck Institute for Infection BiologyBerlin, GermanyThe Laboratory for Molecular Infection Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå UniversityUmeå, SwedenHumboldt UniversityBerlin, GermanyFaculty of Natural Sciences, Institute of Microbiology, Leibniz UniversitätHannover, GermanyHere, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.http://journal.frontiersin.org/article/10.3389/fmolb.2017.00044/fullAAA+ protease complexesHsp100/Clp proteinsBacillus subtilisprotein quality controlchaperonesregulatory proteolysis |
| spellingShingle | Alexander K. W. Elsholz Marlene S. Birk Emmanuelle Charpentier Emmanuelle Charpentier Emmanuelle Charpentier Kürşad Turgay Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis Frontiers in Molecular Biosciences AAA+ protease complexes Hsp100/Clp proteins Bacillus subtilis protein quality control chaperones regulatory proteolysis |
| title | Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis |
| title_full | Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis |
| title_fullStr | Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis |
| title_full_unstemmed | Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis |
| title_short | Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis |
| title_sort | functional diversity of aaa protease complexes in bacillus subtilis |
| topic | AAA+ protease complexes Hsp100/Clp proteins Bacillus subtilis protein quality control chaperones regulatory proteolysis |
| url | http://journal.frontiersin.org/article/10.3389/fmolb.2017.00044/full |
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