Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.

Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and exhibit a delay in axonal degeneration. Current...

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Bibliographic Details
Main Authors: R Grace Zhai, Yu Cao, P Robin Hiesinger, Yi Zhou, Sunil Q Mehta, Karen L Schulze, Patrik Verstreken, Hugo J Bellen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1665629?pdf=render

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