Fluopsin C for Treating Multidrug-Resistant Infections: In vitro Activity Against Clinically Important Strains and in vivo Efficacy Against Carbapenemase-Producing Klebsiella pneumoniae

Fluopsin C for Treating Multidrug-Resistant Infections: In vitro Activity Against Clinically Important Strains and in vivo Efficacy Against Carbapenemase-Producing Klebsiella pneumoniae

The increasing emergence of multidrug-resistant (MDR) organisms in hospital infections is causing a global public health crisis. The development of drugs with effective antibiotic action against such agents is of the highest priority. In the present study, the action of Fluopsin C against MDR clinic...

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Bibliographic Details
Main Authors: Miguel Octavio Pérez Navarro, Ane Stefano Simionato, Juan Carlos Bedoya Pérez, André Riedi Barazetti, Janaina Emiliano, Erika Tyemi Goya Niekawa, Matheus Felipe de Lima Andreata, Fluvio Modolon, Mickely Liuti Dealis, Eduardo José de Almeida Araújo, Thalita Massi Carlos, Odair José Scarpelim, Denise Brentan da Silva, Andreas Lazaros Chryssafidis, Per Bruheim, Galdino Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
antibiotic
murine sepsis model
resistant mutant
electronic microscopy
histopathology
metalloantibiotic
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02431/full

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