Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems

Abstract Functional designing of nanogels has become an attractive domain of biomedical engineering to develop bioactive materials with innovative features for the human healthcare system. Nanosilver has attracted enormous attention due to its wide antimicrobial spectrum and ability to kill almost a...

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Main Authors: Sadiya Anjum, Bhuvanesh Gupta
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Global Challenges
Subjects:
Online Access:https://doi.org/10.1002/gch2.201800044
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author Sadiya Anjum
Bhuvanesh Gupta
author_facet Sadiya Anjum
Bhuvanesh Gupta
author_sort Sadiya Anjum
collection DOAJ
description Abstract Functional designing of nanogels has become an attractive domain of biomedical engineering to develop bioactive materials with innovative features for the human healthcare system. Nanosilver has attracted enormous attention due to its wide antimicrobial spectrum and ability to kill almost all types of bacteria in its vicinity. However, the most crucial challenge for bioscientists is the lack of binding ability of nanosilver with the material surfaces that allow nanosilver to leach out to the surrounding tissue and exert toxicity while the biomaterial is in contact with the living system. Designing nanosilver within a nanogel confinement offers enormous possibilities to develop functional bioactive nanoparticles that may be bonded to any biomaterial surface via the nanogel functionality. This approach requires the proper combination of material science with nanotechnology and biotechnology to innovate interesting domain of functional nanogels with unique features. This work aims at providing a critical review on the current progress, approaches, and vision in designing nanosilver‐entrapped nanogel particles with diverse functionality, and their bioactivity against microorganisms for human healthcare devices.
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spelling doaj.art-c1773ce3f8144e0096fc73ab3ac74d212023-08-14T09:40:37ZengWileyGlobal Challenges2056-66462018-10-01210n/an/a10.1002/gch2.201800044Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare SystemsSadiya Anjum0Bhuvanesh Gupta1Bioengineering Laboratory Department of Textile Technology Indian Institute of Technology New Delhi 110016 IndiaBioengineering Laboratory Department of Textile Technology Indian Institute of Technology New Delhi 110016 IndiaAbstract Functional designing of nanogels has become an attractive domain of biomedical engineering to develop bioactive materials with innovative features for the human healthcare system. Nanosilver has attracted enormous attention due to its wide antimicrobial spectrum and ability to kill almost all types of bacteria in its vicinity. However, the most crucial challenge for bioscientists is the lack of binding ability of nanosilver with the material surfaces that allow nanosilver to leach out to the surrounding tissue and exert toxicity while the biomaterial is in contact with the living system. Designing nanosilver within a nanogel confinement offers enormous possibilities to develop functional bioactive nanoparticles that may be bonded to any biomaterial surface via the nanogel functionality. This approach requires the proper combination of material science with nanotechnology and biotechnology to innovate interesting domain of functional nanogels with unique features. This work aims at providing a critical review on the current progress, approaches, and vision in designing nanosilver‐entrapped nanogel particles with diverse functionality, and their bioactivity against microorganisms for human healthcare devices.https://doi.org/10.1002/gch2.201800044bacteriabiomaterialshealthcareinfectionsnanogelsnanosilver
spellingShingle Sadiya Anjum
Bhuvanesh Gupta
Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
Global Challenges
bacteria
biomaterials
healthcare
infections
nanogels
nanosilver
title Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
title_full Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
title_fullStr Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
title_full_unstemmed Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
title_short Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
title_sort bioengineering of functional nanosilver nanogels for smart healthcare systems
topic bacteria
biomaterials
healthcare
infections
nanogels
nanosilver
url https://doi.org/10.1002/gch2.201800044
work_keys_str_mv AT sadiyaanjum bioengineeringoffunctionalnanosilvernanogelsforsmarthealthcaresystems
AT bhuvaneshgupta bioengineeringoffunctionalnanosilvernanogelsforsmarthealthcaresystems