A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein

Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two leading causes of severe respiratory infections in children, the elderly, and immunocompromised patients. The fusion (F) protein is the major target of neutralizing antibodies. Recent developments in stabilizing the pre-fusio...

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Bibliographic Details
Main Authors: Jiachen Huang, Rose J. Miller, Jarrod J. Mousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
RSV (respiratory syncytial virus)
human metapneumovirus (hMPV)
vaccine
structure-based vaccine design
neutralizing antibodies
fusion protein
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.941865/full

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