A method to estimate the contribution of rare coding variants to complex trait heritability

A method to estimate the contribution of rare coding variants to complex trait heritability

Abstract It has been postulated that rare coding variants (RVs; MAF < 0.01) contribute to the “missing” heritability of complex traits. We developed a framework, the Rare variant heritability (RARity) estimator, to assess RV heritability (h 2 RV) without assuming a particular genetic architecture...

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Bibliographic Details
Main Authors:	Nazia Pathan, Wei Q. Deng, Matteo Di Scipio, Mohammad Khan, Shihong Mao, Robert W. Morton, Ricky Lali, Marie Pigeyre, Michael R. Chong, Guillaume Paré
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-45407-8

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