Cortical organization of inhibition-related functions and modulation by psychopathology
Individual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psyc...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-06-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00271/full |
| _version_ | 1818149239434248192 |
|---|---|
| author | Stacie L. Warren Stacie L. Warren Laura D. Crocker Jeffrey Martin Spielberg Jeffrey Martin Spielberg Anna S Engels Anna S Engels Marie T Banich Bradley P Sutton Gregory A Miller Gregory A Miller Gregory A Miller Wendy eHeller |
| author_facet | Stacie L. Warren Stacie L. Warren Laura D. Crocker Jeffrey Martin Spielberg Jeffrey Martin Spielberg Anna S Engels Anna S Engels Marie T Banich Bradley P Sutton Gregory A Miller Gregory A Miller Gregory A Miller Wendy eHeller |
| author_sort | Stacie L. Warren |
| collection | DOAJ |
| description | Individual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psychopathology. The present study tested the hypothesis that activity in common and distinct brain regions would be associated with an ecologically sensitive, self-report measure of inhibition and a laboratory performance measure of prepotent response inhibition. Results indicated that sub-regions of DLPFC distinguished measures of inhibition, whereas left inferior frontal gyrus and bilateral inferior parietal cortex were associated with both types of inhibition. Additionally, co-occurring anxiety and depression modulated neural activity in select brain regions associated with response inhibition. Results imply that specific combinations of anxiety and depression dimensions are associated with failure to implement top-down attentional control as reflected in inefficient recruitment of posterior DLPFC and increased activation in regions associated with threat (MTG) and worry (BA10). Present findings elucidate possible neural mechanisms of interference that could help explain executive control deficits in psychopathology. |
| first_indexed | 2024-12-11T13:03:53Z |
| format | Article |
| id | doaj.art-c178ea3185704815ae61c68267146a7c |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T13:03:53Z |
| publishDate | 2013-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-c178ea3185704815ae61c68267146a7c2022-12-22T01:06:22ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-06-01710.3389/fnhum.2013.0027147011Cortical organization of inhibition-related functions and modulation by psychopathologyStacie L. Warren0Stacie L. Warren1Laura D. Crocker2Jeffrey Martin Spielberg3Jeffrey Martin Spielberg4Anna S Engels5Anna S Engels6Marie T Banich7Bradley P Sutton8Gregory A Miller9Gregory A Miller10Gregory A Miller11Wendy eHeller12University of Illinois Urbana ChampaignSt. Louis Department of Veteran AffairsUniversity of Illinois Urbana ChampaignUniversity of Illinois Urbana ChampaignUniversity of California, BerkeleyUniversity of Illinois Urbana ChampaignPennsylvania State UniversityUniversity of Colorado at BoulderUniversity of Illinois Urbana ChampaignUniversity of Illinois Urbana ChampaignUniversity of DelawareUniversity of KonstanzUniversity of Illinois Urbana ChampaignIndividual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psychopathology. The present study tested the hypothesis that activity in common and distinct brain regions would be associated with an ecologically sensitive, self-report measure of inhibition and a laboratory performance measure of prepotent response inhibition. Results indicated that sub-regions of DLPFC distinguished measures of inhibition, whereas left inferior frontal gyrus and bilateral inferior parietal cortex were associated with both types of inhibition. Additionally, co-occurring anxiety and depression modulated neural activity in select brain regions associated with response inhibition. Results imply that specific combinations of anxiety and depression dimensions are associated with failure to implement top-down attentional control as reflected in inefficient recruitment of posterior DLPFC and increased activation in regions associated with threat (MTG) and worry (BA10). Present findings elucidate possible neural mechanisms of interference that could help explain executive control deficits in psychopathology.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00271/fullAnxietyDepressioninhibitionattentional controlDLPFC |
| spellingShingle | Stacie L. Warren Stacie L. Warren Laura D. Crocker Jeffrey Martin Spielberg Jeffrey Martin Spielberg Anna S Engels Anna S Engels Marie T Banich Bradley P Sutton Gregory A Miller Gregory A Miller Gregory A Miller Wendy eHeller Cortical organization of inhibition-related functions and modulation by psychopathology Frontiers in Human Neuroscience Anxiety Depression inhibition attentional control DLPFC |
| title | Cortical organization of inhibition-related functions and modulation by psychopathology |
| title_full | Cortical organization of inhibition-related functions and modulation by psychopathology |
| title_fullStr | Cortical organization of inhibition-related functions and modulation by psychopathology |
| title_full_unstemmed | Cortical organization of inhibition-related functions and modulation by psychopathology |
| title_short | Cortical organization of inhibition-related functions and modulation by psychopathology |
| title_sort | cortical organization of inhibition related functions and modulation by psychopathology |
| topic | Anxiety Depression inhibition attentional control DLPFC |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00271/full |
| work_keys_str_mv | AT stacielwarren corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT stacielwarren corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT lauradcrocker corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT jeffreymartinspielberg corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT jeffreymartinspielberg corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT annasengels corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT annasengels corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT marietbanich corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT bradleypsutton corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT gregoryamiller corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT gregoryamiller corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT gregoryamiller corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology AT wendyeheller corticalorganizationofinhibitionrelatedfunctionsandmodulationbypsychopathology |