Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma
Gallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract. The progression from gallbladder adenoma to carcinoma remains unclear. The p53 gene is the most frequently mutated tumor suppressor in human cancers. In this study, we analyzed the expression patterns...
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| Format: | Article |
| Language: | English |
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Wiley
2006-02-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09702219 |
| _version_ | 1831790299582562304 |
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| author | Shen-Nien Wang Shin-Chang Chung Kun-Bow Tsai Chee-Yin Chai Wen-Tsun Chang Kung-Kai Kuo Jong-Shyone Chen King-Teh Lee |
| author_facet | Shen-Nien Wang Shin-Chang Chung Kun-Bow Tsai Chee-Yin Chai Wen-Tsun Chang Kung-Kai Kuo Jong-Shyone Chen King-Teh Lee |
| author_sort | Shen-Nien Wang |
| collection | DOAJ |
| description | Gallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract. The progression from gallbladder adenoma to carcinoma remains unclear. The p53 gene is the most frequently mutated tumor suppressor in human cancers. In this study, we analyzed the expression patterns of the p53 protein in 22 cases of GBC, 17 cases of precursor lesions (16 gallbladder adenomas and 1 cystadenoma), and 15 cases of normal epithelia using immunohistochemical analysis. The results were correlated with clinicopathologic characteristics. We found that p53 expression was significantly increased in 59.1% (13/22) of GBC cases and in 17.6% (3/17) of gallbladder adenoma cases (p = 0.009). There was no p53 expression in the 15 cases of normal epithelia, and a significant difference was shown between normal epithelium and GBC cases (p < 0.001). In addition, the expression pattern of p53 protein did not show any significant correlation with the histologic type and the differentiation grade of GBC. In conclusion, we suggest that the aberrant p53 expression may play a role in the occurrence of GBC. |
| first_indexed | 2024-12-22T14:27:58Z |
| format | Article |
| id | doaj.art-c178f78b0b754486a0868ebb4d90fcbf |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-22T14:27:58Z |
| publishDate | 2006-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-c178f78b0b754486a0868ebb4d90fcbf2022-12-21T18:22:49ZengWileyKaohsiung Journal of Medical Sciences1607-551X2006-02-01222535910.1016/S1607-551X(09)70221-9Aberrant P53 Expression and the Development of Gallbladder Carcinoma and AdenomaShen-Nien Wang0Shin-Chang Chung1Kun-Bow Tsai2Chee-Yin Chai3Wen-Tsun Chang4Kung-Kai Kuo5Jong-Shyone Chen6King-Teh Lee7Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pathology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pathology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract. The progression from gallbladder adenoma to carcinoma remains unclear. The p53 gene is the most frequently mutated tumor suppressor in human cancers. In this study, we analyzed the expression patterns of the p53 protein in 22 cases of GBC, 17 cases of precursor lesions (16 gallbladder adenomas and 1 cystadenoma), and 15 cases of normal epithelia using immunohistochemical analysis. The results were correlated with clinicopathologic characteristics. We found that p53 expression was significantly increased in 59.1% (13/22) of GBC cases and in 17.6% (3/17) of gallbladder adenoma cases (p = 0.009). There was no p53 expression in the 15 cases of normal epithelia, and a significant difference was shown between normal epithelium and GBC cases (p < 0.001). In addition, the expression pattern of p53 protein did not show any significant correlation with the histologic type and the differentiation grade of GBC. In conclusion, we suggest that the aberrant p53 expression may play a role in the occurrence of GBC.http://www.sciencedirect.com/science/article/pii/S1607551X09702219p53immunohistochemistrygallbladder adenomagallbladder carcinoma |
| spellingShingle | Shen-Nien Wang Shin-Chang Chung Kun-Bow Tsai Chee-Yin Chai Wen-Tsun Chang Kung-Kai Kuo Jong-Shyone Chen King-Teh Lee Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma Kaohsiung Journal of Medical Sciences p53 immunohistochemistry gallbladder adenoma gallbladder carcinoma |
| title | Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma |
| title_full | Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma |
| title_fullStr | Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma |
| title_full_unstemmed | Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma |
| title_short | Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma |
| title_sort | aberrant p53 expression and the development of gallbladder carcinoma and adenoma |
| topic | p53 immunohistochemistry gallbladder adenoma gallbladder carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09702219 |
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