Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

The spinal cord is extremely vulnerable to ischemia-reperfusion (I/R) injury, and the mitochondrion is the most crucial interventional target. Rapamycin can promote autophagy and exert neuroprotective effects in several diseases of the central nervous system. However, the impact of rapamycin via mod...

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Bibliographic Details
Main Authors: Qiang Li, Shane Gao, Zhanrong Kang, Meiyan Zhang, Xin Zhao, Yu Zhai, Jianming Huang, Guo-Yuan Yang, Wanju Sun, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
apoptosis
mitophagy
ischemia-reperfusion injury
rapamycin
spinal cord
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00865/full

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