Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
Background: Depression appears to be a common complication in patients during and post–COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354620301381 |
| _version_ | 1831559354790182912 |
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| author | Orna Alpert Leonid Begun Patrik Garren, B.A. Ramon Solhkhah |
| author_facet | Orna Alpert Leonid Begun Patrik Garren, B.A. Ramon Solhkhah |
| author_sort | Orna Alpert |
| collection | DOAJ |
| description | Background: Depression appears to be a common complication in patients during and post–COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a new light on future treatment options for both disorders. Objective: This review demonstrates the role of interleukins in COVID-19 pathogenesis and their role in depression. Results: We described cases we have treated as an example for the dual role interleukins have in COVID-19 infection and depression and reviewed approximately 70 articles focusing on the role of interleukins in cytokine storm syndrome and depression. Conclusion: This review highlights the key features of cytokines in both diseases. As the scientific community has more time to recover and process the effect of the current pandemic, we believe that additional research will pave the way to diverse pathways to treat depression in these patient and others. |
| first_indexed | 2024-12-17T05:27:42Z |
| format | Article |
| id | doaj.art-c17a85c6819f4452a960729c61fc2813 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-17T05:27:42Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-c17a85c6819f4452a960729c61fc28132022-12-21T22:01:49ZengElsevierBrain, Behavior, & Immunity - Health2666-35462020-12-019100173Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reportsOrna Alpert0Leonid Begun1Patrik Garren, B.A.2Ramon Solhkhah3Department of Psychiatry & Behavioral Health, Jersey Shore University Medical Center and Hackensack Meridian School of Medicine at Seton Hall University, United States; Corresponding author.Department of Psychiatry, Jersey Shore University Hospital, United StatesThe University of Pennsylvania, United StatesDepartment of Psychiatry & Behavioral Health, Jersey Shore University Medical Center and Hackensack Meridian School of Medicine at Seton Hall University, United StatesBackground: Depression appears to be a common complication in patients during and post–COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a new light on future treatment options for both disorders. Objective: This review demonstrates the role of interleukins in COVID-19 pathogenesis and their role in depression. Results: We described cases we have treated as an example for the dual role interleukins have in COVID-19 infection and depression and reviewed approximately 70 articles focusing on the role of interleukins in cytokine storm syndrome and depression. Conclusion: This review highlights the key features of cytokines in both diseases. As the scientific community has more time to recover and process the effect of the current pandemic, we believe that additional research will pave the way to diverse pathways to treat depression in these patient and others.http://www.sciencedirect.com/science/article/pii/S2666354620301381Inflammatory cytokinesInterleukin-6Interleukin-10DepressionSARS-CoV-2 |
| spellingShingle | Orna Alpert Leonid Begun Patrik Garren, B.A. Ramon Solhkhah Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports Brain, Behavior, & Immunity - Health Inflammatory cytokines Interleukin-6 Interleukin-10 Depression SARS-CoV-2 |
| title | Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports |
| title_full | Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports |
| title_fullStr | Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports |
| title_full_unstemmed | Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports |
| title_short | Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports |
| title_sort | cytokine storm induced new onset depression in patients with covid 19 a new look into the association between depression and cytokines two case reports |
| topic | Inflammatory cytokines Interleukin-6 Interleukin-10 Depression SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2666354620301381 |
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