Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins
<i>Fusarium graminearum</i> is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today....
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/405 |
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| author | Mathilde Montibus Xavier Vitrac Véronique Coma Anne Loron Laetitia Pinson-Gadais Nathalie Ferrer Marie-Noëlle Verdal-Bonnin Julien Gabaston Pierre Waffo-Téguo Florence Richard-Forget Vessela Atanasova |
| author_facet | Mathilde Montibus Xavier Vitrac Véronique Coma Anne Loron Laetitia Pinson-Gadais Nathalie Ferrer Marie-Noëlle Verdal-Bonnin Julien Gabaston Pierre Waffo-Téguo Florence Richard-Forget Vessela Atanasova |
| author_sort | Mathilde Montibus |
| collection | DOAJ |
| description | <i>Fusarium graminearum</i> is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by <i>F. graminearum</i>. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by <i>F. graminearum</i>. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling <i>F. graminearum</i> and its production of mycotoxins. |
| first_indexed | 2024-03-09T04:49:11Z |
| format | Article |
| id | doaj.art-c17c5a335e9a4f1da3b204ec21abfffd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:49:11Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c17c5a335e9a4f1da3b204ec21abfffd2023-12-03T13:12:30ZengMDPI AGMolecules1420-30492021-01-0126240510.3390/molecules26020405Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of MycotoxinsMathilde Montibus0Xavier Vitrac1Véronique Coma2Anne Loron3Laetitia Pinson-Gadais4Nathalie Ferrer5Marie-Noëlle Verdal-Bonnin6Julien Gabaston7Pierre Waffo-Téguo8Florence Richard-Forget9Vessela Atanasova10Institut Technologique FCBA, Allée de Boutaut, BP 227, F-33028 Bordeaux, FranceLaboratoire Phenobio SAS, ZA Les Pins Verts, 22 Allée de Migelane, F-33650 Saucats, FranceLaboratoire de Chimie des Polymères Organiques, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 16 Avenue Pey-Berland, F-33600 Pessac, FranceLaboratoire de Chimie des Polymères Organiques, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 16 Avenue Pey-Berland, F-33600 Pessac, FranceINRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, FranceINRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, FranceINRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, FranceFaculté des Sciences Pharmaceutiques, Unité de Recherche Œnologie, EA 4577, USC 1366 INRAE, Equipe Molécules d’Intérêt Biologique-ISVV, Université de Bordeaux, F-33882 Villenave d’Ornon, FranceFaculté des Sciences Pharmaceutiques, Unité de Recherche Œnologie, EA 4577, USC 1366 INRAE, Equipe Molécules d’Intérêt Biologique-ISVV, Université de Bordeaux, F-33882 Villenave d’Ornon, FranceINRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, FranceINRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, France<i>Fusarium graminearum</i> is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by <i>F. graminearum</i>. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by <i>F. graminearum</i>. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling <i>F. graminearum</i> and its production of mycotoxins.https://www.mdpi.com/1420-3049/26/2/405<i>Fusarium graminearum</i>type B trichothecenesnatural extractsecological strategiesbiofungicides |
| spellingShingle | Mathilde Montibus Xavier Vitrac Véronique Coma Anne Loron Laetitia Pinson-Gadais Nathalie Ferrer Marie-Noëlle Verdal-Bonnin Julien Gabaston Pierre Waffo-Téguo Florence Richard-Forget Vessela Atanasova Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins Molecules <i>Fusarium graminearum</i> type B trichothecenes natural extracts ecological strategies biofungicides |
| title | Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins |
| title_full | Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins |
| title_fullStr | Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins |
| title_full_unstemmed | Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins |
| title_short | Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control <i>Fusarium graminearum</i> and the Production of Mycotoxins |
| title_sort | screening of wood forest and vine by products as sources of new drugs for sustainable strategies to control i fusarium graminearum i and the production of mycotoxins |
| topic | <i>Fusarium graminearum</i> type B trichothecenes natural extracts ecological strategies biofungicides |
| url | https://www.mdpi.com/1420-3049/26/2/405 |
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