Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual
Introduction: 4-fluoroamphetamine (4-FA) is a novel psychoactive stimulant with a global presence on the drug market. Despite the popularity of 4-FA, data on severe adverse effects are scarce. We present a case of laboratory confirmed 4-FA mono intoxication causing acute heart failure due to a rever...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750020304455 |
| _version_ | 1818647815608336384 |
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| author | R.S.D. van der Pas F.M.J. Gresnigt L. Wansink E.J.F. Franssen R.K. Riezebos |
| author_facet | R.S.D. van der Pas F.M.J. Gresnigt L. Wansink E.J.F. Franssen R.K. Riezebos |
| author_sort | R.S.D. van der Pas |
| collection | DOAJ |
| description | Introduction: 4-fluoroamphetamine (4-FA) is a novel psychoactive stimulant with a global presence on the drug market. Despite the popularity of 4-FA, data on severe adverse effects are scarce. We present a case of laboratory confirmed 4-FA mono intoxication causing acute heart failure due to a reverse type Takotsubo cardiomyopathy. Case: A 20-year-old male with no previous medical history and no reported previous drug use, presented to the emergency department (ED) with complaints of headache, nausea and vomiting, approximately 4.5 h after the ingestion of a single 4-FA pill. After 30 min his condition deteriorated with severe hypertension, tachycardia and respiratory failure. Echocardiography showed a reverse type Takotsubo cardiomyopathy. The patient was successfully treated with mechanical ventilation, a phosphodiesterase-3-inhibitor (PDE3-inhibitor) and diuretics. Three months after hospital admission, the patient was free of complaints and his left ventricular function fully recovered. Conclusion: Recreational use of 4-FA may result in acute onset life-threatening cardiorespiratory toxicity, preceded by severe hypertension, even in drug-naïve patients without any medical history. Emergency physicians and cardiologists should be cautious not to underestimate life-threatening 4-FA complications. |
| first_indexed | 2024-12-17T01:08:32Z |
| format | Article |
| id | doaj.art-c17f5c31179146539714ae8edc1a413c |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-17T01:08:32Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-c17f5c31179146539714ae8edc1a413c2022-12-21T22:09:12ZengElsevierToxicology Reports2214-75002020-01-01716291633Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individualR.S.D. van der Pas0F.M.J. Gresnigt1L. Wansink2E.J.F. Franssen3R.K. Riezebos4Emergency medicine at OLVG hospital, Amsterdam, the Netherlands; Emergency registrars at Sint Antonius hospital, Nieuwegein, the NetherlandsEmergency Physician at OLVG Hospital, Amsterdam, the Netherlands; Corresponding author at: Emergency physician at OLVG hospital, Oosterpark 9, 1091 AC, Amsterdam, the Netherlands.Emergency medicine at OLVG hospital, Amsterdam, the Netherlands; Emergency Physician at Dijklander ziekenhuis, Hoorn, the NetherlandsPharmacist at OLVG Hospital, Amsterdam, the NetherlandsCardiologist at OLVG Hospital, Amsterdam, the NetherlandsIntroduction: 4-fluoroamphetamine (4-FA) is a novel psychoactive stimulant with a global presence on the drug market. Despite the popularity of 4-FA, data on severe adverse effects are scarce. We present a case of laboratory confirmed 4-FA mono intoxication causing acute heart failure due to a reverse type Takotsubo cardiomyopathy. Case: A 20-year-old male with no previous medical history and no reported previous drug use, presented to the emergency department (ED) with complaints of headache, nausea and vomiting, approximately 4.5 h after the ingestion of a single 4-FA pill. After 30 min his condition deteriorated with severe hypertension, tachycardia and respiratory failure. Echocardiography showed a reverse type Takotsubo cardiomyopathy. The patient was successfully treated with mechanical ventilation, a phosphodiesterase-3-inhibitor (PDE3-inhibitor) and diuretics. Three months after hospital admission, the patient was free of complaints and his left ventricular function fully recovered. Conclusion: Recreational use of 4-FA may result in acute onset life-threatening cardiorespiratory toxicity, preceded by severe hypertension, even in drug-naïve patients without any medical history. Emergency physicians and cardiologists should be cautious not to underestimate life-threatening 4-FA complications.http://www.sciencedirect.com/science/article/pii/S22147500203044554-FluoroamphetamineAdverse eventsReverse type Takotsubo cardiomyopathyCardiogenic shock |
| spellingShingle | R.S.D. van der Pas F.M.J. Gresnigt L. Wansink E.J.F. Franssen R.K. Riezebos Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual Toxicology Reports 4-Fluoroamphetamine Adverse events Reverse type Takotsubo cardiomyopathy Cardiogenic shock |
| title | Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual |
| title_full | Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual |
| title_fullStr | Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual |
| title_full_unstemmed | Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual |
| title_short | Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual |
| title_sort | acute onset heart failure due to reverse type takotsubo cardiomyopathy caused by a single dose of 4 fluoroamphetamine in a healthy young individual |
| topic | 4-Fluoroamphetamine Adverse events Reverse type Takotsubo cardiomyopathy Cardiogenic shock |
| url | http://www.sciencedirect.com/science/article/pii/S2214750020304455 |
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