Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms
Caenorhabditis elegans, a non-parasitic nematode emerges as a relevant and powerful candidate as an in vivo model for microorganisms-microorganisms and microorganisms-host interactions studies. Experiments have demonstrated the probiotic potential of bacteria since they can provide to the worm a lon...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2020.00135/full |
| _version_ | 1829472885606973440 |
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| author | Cyril Poupet Christophe Chassard Adrien Nivoliez Stéphanie Bornes |
| author_facet | Cyril Poupet Christophe Chassard Adrien Nivoliez Stéphanie Bornes |
| author_sort | Cyril Poupet |
| collection | DOAJ |
| description | Caenorhabditis elegans, a non-parasitic nematode emerges as a relevant and powerful candidate as an in vivo model for microorganisms-microorganisms and microorganisms-host interactions studies. Experiments have demonstrated the probiotic potential of bacteria since they can provide to the worm a longer lifespan, an increased resistance to pathogens and to oxidative or heat stresses. Probiotics are used to prevent or treat microbiota dysbiosis and associated pathologies but the molecular mechanisms underlying their capacities are still unknown. Beyond safety and healthy aspects of probiotics, C. elegans represents a powerful way to design large-scale studies to explore transkingdom interactions and to solve questioning about the molecular aspect of these interactions. Future challenges and opportunities would be to validate C. elegans as an in vivo tool for high-throughput screening of microorganisms for their potential probiotic use on human health and to enlarge the panels of microorganisms studied as well as the human diseases investigated. |
| first_indexed | 2024-12-14T02:20:37Z |
| format | Article |
| id | doaj.art-c17fbc9d0b954e27be4a23dd7d9428e7 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-14T02:20:37Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-c17fbc9d0b954e27be4a23dd7d9428e72022-12-21T23:20:30ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2020-08-01710.3389/fnut.2020.00135535982Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial MicroorganismsCyril Poupet0Christophe Chassard1Adrien Nivoliez2Stéphanie Bornes3Université Clermont Auvergne, INRAE, VetAgro Sup, UMRF, Aurillac, FranceUniversité Clermont Auvergne, INRAE, VetAgro Sup, UMRF, Aurillac, FranceBiose Industrie, Aurillac, FranceUniversité Clermont Auvergne, INRAE, VetAgro Sup, UMRF, Aurillac, FranceCaenorhabditis elegans, a non-parasitic nematode emerges as a relevant and powerful candidate as an in vivo model for microorganisms-microorganisms and microorganisms-host interactions studies. Experiments have demonstrated the probiotic potential of bacteria since they can provide to the worm a longer lifespan, an increased resistance to pathogens and to oxidative or heat stresses. Probiotics are used to prevent or treat microbiota dysbiosis and associated pathologies but the molecular mechanisms underlying their capacities are still unknown. Beyond safety and healthy aspects of probiotics, C. elegans represents a powerful way to design large-scale studies to explore transkingdom interactions and to solve questioning about the molecular aspect of these interactions. Future challenges and opportunities would be to validate C. elegans as an in vivo tool for high-throughput screening of microorganisms for their potential probiotic use on human health and to enlarge the panels of microorganisms studied as well as the human diseases investigated.https://www.frontiersin.org/articles/10.3389/fnut.2020.00135/fullCaenorhabditis elegansprobioticslifespanpathogensstress responseimmunity |
| spellingShingle | Cyril Poupet Christophe Chassard Adrien Nivoliez Stéphanie Bornes Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms Frontiers in Nutrition Caenorhabditis elegans probiotics lifespan pathogens stress response immunity |
| title | Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms |
| title_full | Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms |
| title_fullStr | Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms |
| title_full_unstemmed | Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms |
| title_short | Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms |
| title_sort | caenorhabditis elegans a host to investigate the probiotic properties of beneficial microorganisms |
| topic | Caenorhabditis elegans probiotics lifespan pathogens stress response immunity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2020.00135/full |
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