Melatonin at repeated doses alleviates hyperglycemia-exacerbated cerebral ischemia-reperfusion injury at 72 h via anti-inflammation and anti-apoptosis

Melatonin at repeated doses alleviates hyperglycemia-exacerbated cerebral ischemia-reperfusion injury at 72 h via anti-inflammation and anti-apoptosis

Objective: We aimed to investigate how hyperglycemia would exacerbate cerebral ischemia-reperfusion injury (CIRI) in a rat model of type 1 diabetes mellitus (T1DM) and explore the beneficial effects of multiple doses of melatonin in T1DM induced CIRI. Method: The T1DM rat model was induced with stre...

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Bibliographic Details
Main Authors: Qian Xu, Raymond Tak Fai Cheung
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:IBRO Neuroscience Reports
Subjects:
Ischemia-reperfusion
Melatonin
Neuroprotective
Normoglycemia
Rats
Type 1 diabetes mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242124000277

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http://www.sciencedirect.com/science/article/pii/S2667242124000277

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