Copper – a novel stimulator of autophagy
Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2020-04-01
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| Series: | Cell Stress |
| Subjects: | |
| Online Access: | http://www.cell-stress.com/researcharticles/2020a-zischka-cell-stress/ |
| _version_ | 1818328596685520896 |
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| author | Hans Zischka Guido Kroemer |
| author_facet | Hans Zischka Guido Kroemer |
| author_sort | Hans Zischka |
| collection | DOAJ |
| description | Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-autophagic kinases ULK1 and ULK2. Chelation of copper or genetic deletion of this copper-binding site inhibits autophagy and hence reduces the fitness of KRAS-induced cancers. These findings suggest that copper chelation might constitute a novel therapeutic intervention on autophagy-dependent malignancies. |
| first_indexed | 2024-12-13T12:34:41Z |
| format | Article |
| id | doaj.art-c181b74508244a7d8da569a4e5426fc8 |
| institution | Directory Open Access Journal |
| issn | 2523-0204 |
| language | English |
| last_indexed | 2024-12-13T12:34:41Z |
| publishDate | 2020-04-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Cell Stress |
| spelling | doaj.art-c181b74508244a7d8da569a4e5426fc82022-12-21T23:45:55ZengShared Science Publishers OGCell Stress2523-02042020-04-0145929410.15698/cst2020.05.218Copper – a novel stimulator of autophagyHans Zischka0Guido Kroemer1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, IN-SERM U1138, Institut Universitaire de France, Paris, France.Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-autophagic kinases ULK1 and ULK2. Chelation of copper or genetic deletion of this copper-binding site inhibits autophagy and hence reduces the fitness of KRAS-induced cancers. These findings suggest that copper chelation might constitute a novel therapeutic intervention on autophagy-dependent malignancies.http://www.cell-stress.com/researcharticles/2020a-zischka-cell-stress/autophagywilson diseasecoppercancerulk1ulk2mek1 |
| spellingShingle | Hans Zischka Guido Kroemer Copper – a novel stimulator of autophagy Cell Stress autophagy wilson disease copper cancer ulk1 ulk2 mek1 |
| title | Copper – a novel stimulator of autophagy |
| title_full | Copper – a novel stimulator of autophagy |
| title_fullStr | Copper – a novel stimulator of autophagy |
| title_full_unstemmed | Copper – a novel stimulator of autophagy |
| title_short | Copper – a novel stimulator of autophagy |
| title_sort | copper a novel stimulator of autophagy |
| topic | autophagy wilson disease copper cancer ulk1 ulk2 mek1 |
| url | http://www.cell-stress.com/researcharticles/2020a-zischka-cell-stress/ |
| work_keys_str_mv | AT hanszischka copperanovelstimulatorofautophagy AT guidokroemer copperanovelstimulatorofautophagy |