Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motor neuron loss is the primary phenotype, leading to muscle weakness and wasting, respiratory failure, and death. Although a portion of ALS cases are linked to one of over 50 unique genes, the vast ma...

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Bibliographic Details
Main Authors: Reilly L. Allison, Jacob W. Adelman, Jenica Abrudan, Raul A. Urrutia, Michael T. Zimmermann, Angela J. Mathison, Allison D. Ebert
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Genes
Subjects:
induced pluripotent stem cells
amyotrophic lateral sclerosis
astrocytes
RNA sequencing
cytokines
anti-inflammatory
Online Access:https://www.mdpi.com/2073-4425/13/2/241

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