Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review)
The review analyzes the etiological and pathogenetic factors (including immunopathogenesis factors) of chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MS), cites data on clinical and pathogenetic characteristics of combined pathology, emphasizes the commonality of risk factors a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2020-12-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12378 |
| _version_ | 1797204628110049280 |
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| author | Olga V. Voronkova Tatyana V. Saprina Ekaterina B. Bukreeva Anastasia P. Zima |
| author_facet | Olga V. Voronkova Tatyana V. Saprina Ekaterina B. Bukreeva Anastasia P. Zima |
| author_sort | Olga V. Voronkova |
| collection | DOAJ |
| description | The review analyzes the etiological and pathogenetic factors (including immunopathogenesis factors) of chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MS), cites data on clinical and pathogenetic characteristics of combined pathology, emphasizes the commonality of risk factors and individual links of pathogenesis in syntropy.The clinical and pathogenetic features of the comorbidity of COPD and MS are closely related to the severity of chronic “metabolic” inflammation induced by elements of adipose tissue. Functional and biochemical disorders recorded in metabolic syndrome (insulin resistance, hyperglycemia, dyslipidemia) are considered as factors contributing to dysfunction of the components of innate and adaptive immunity.The review formulates a number of unresolved issues of the pathogenesis of comorbid pathology, the study of which is necessary to search for the mutual aggravating effect of COPD and MS mechanisms. In view of the clinical and laboratory metabolic syndrome equivalents variety, the authors emphasize the relevance of future studies of the pathogenetic features of chronic inflammation associated with the comorbidity of the main components of metabolic syndrome and COPD, to develop effective methods of prevention and pathogenetic therapy of comorbid pathology. |
| first_indexed | 2024-03-08T09:12:32Z |
| format | Article |
| id | doaj.art-c182900fd85747d784c40e9fc86840b6 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:38:15Z |
| publishDate | 2020-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-c182900fd85747d784c40e9fc86840b62024-04-16T16:16:12ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242020-12-0117329229810.14341/omet1237810848Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review)Olga V. Voronkova0Tatyana V. Saprina1Ekaterina B. Bukreeva2Anastasia P. Zima3Siberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityThe review analyzes the etiological and pathogenetic factors (including immunopathogenesis factors) of chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MS), cites data on clinical and pathogenetic characteristics of combined pathology, emphasizes the commonality of risk factors and individual links of pathogenesis in syntropy.The clinical and pathogenetic features of the comorbidity of COPD and MS are closely related to the severity of chronic “metabolic” inflammation induced by elements of adipose tissue. Functional and biochemical disorders recorded in metabolic syndrome (insulin resistance, hyperglycemia, dyslipidemia) are considered as factors contributing to dysfunction of the components of innate and adaptive immunity.The review formulates a number of unresolved issues of the pathogenesis of comorbid pathology, the study of which is necessary to search for the mutual aggravating effect of COPD and MS mechanisms. In view of the clinical and laboratory metabolic syndrome equivalents variety, the authors emphasize the relevance of future studies of the pathogenetic features of chronic inflammation associated with the comorbidity of the main components of metabolic syndrome and COPD, to develop effective methods of prevention and pathogenetic therapy of comorbid pathology.https://www.omet-endojournals.ru/jour/article/view/12378comorbiditychronic obstructive pulmonary diseasemetabolic syndromechronic inflammationpathogenesis |
| spellingShingle | Olga V. Voronkova Tatyana V. Saprina Ekaterina B. Bukreeva Anastasia P. Zima Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review) Ожирение и метаболизм comorbidity chronic obstructive pulmonary disease metabolic syndrome chronic inflammation pathogenesis |
| title | Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review) |
| title_full | Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review) |
| title_fullStr | Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review) |
| title_full_unstemmed | Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review) |
| title_short | Etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity COPD and metabolic syndrome (review) |
| title_sort | etiopathogenetic parallels and unresolved issues of pathogenesis of comorbidity copd and metabolic syndrome review |
| topic | comorbidity chronic obstructive pulmonary disease metabolic syndrome chronic inflammation pathogenesis |
| url | https://www.omet-endojournals.ru/jour/article/view/12378 |
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