Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development
Pregnancy complications occur frequently and are particularly prevalent during the first trimester. They are caused by a multitude of factors, including karyotypic, genetic or environmental conditions, congenital infections and inflammation. The molecular mechanisms leading to placental complication...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Académie des sciences
2021-07-01
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| Series: | Comptes Rendus Biologies |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.54/ |
| _version_ | 1797651270583975936 |
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| author | Buchrieser, Julian Schwartz, Olivier |
| author_facet | Buchrieser, Julian Schwartz, Olivier |
| author_sort | Buchrieser, Julian |
| collection | DOAJ |
| description | Pregnancy complications occur frequently and are particularly prevalent during the first trimester. They are caused by a multitude of factors, including karyotypic, genetic or environmental conditions, congenital infections and inflammation. The molecular mechanisms leading to placental complications under inflammatory conditions remain unclear. In this review, we discuss how uncontrolled inflammation, triggered by viral infections or other diseases can lead to placental complications. We first highlight the importance of syncytins, ancestral retroviral genes co-opted by mammals including humans, millions of years ago for the process of placenta formation. We then focus on recent advances elucidating how interferon-induced transmembrane (IFITM) proteins, antiviral proteins rendering cells refractory to viral infections, interfere with placental development. |
| first_indexed | 2024-03-11T16:13:33Z |
| format | Article |
| id | doaj.art-c1832f4e0d6c43a194bee82fc8cc4823 |
| institution | Directory Open Access Journal |
| issn | 1768-3238 |
| language | English |
| last_indexed | 2024-03-11T16:13:33Z |
| publishDate | 2021-07-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj.art-c1832f4e0d6c43a194bee82fc8cc48232023-10-24T14:25:19ZengAcadémie des sciencesComptes Rendus Biologies1768-32382021-07-01344214515610.5802/crbiol.5410.5802/crbiol.54Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental developmentBuchrieser, Julian0https://orcid.org/0000-0003-4790-7577Schwartz, Olivier1https://orcid.org/0000-0002-0729-1475Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France; CNRS-UMR3569, Paris, FranceVirus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France; CNRS-UMR3569, Paris, FrancePregnancy complications occur frequently and are particularly prevalent during the first trimester. They are caused by a multitude of factors, including karyotypic, genetic or environmental conditions, congenital infections and inflammation. The molecular mechanisms leading to placental complications under inflammatory conditions remain unclear. In this review, we discuss how uncontrolled inflammation, triggered by viral infections or other diseases can lead to placental complications. We first highlight the importance of syncytins, ancestral retroviral genes co-opted by mammals including humans, millions of years ago for the process of placenta formation. We then focus on recent advances elucidating how interferon-induced transmembrane (IFITM) proteins, antiviral proteins rendering cells refractory to viral infections, interfere with placental development.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.54/PlacentaInterferonsIFITMsSyncytiotrophoblastCell–cell fusion |
| spellingShingle | Buchrieser, Julian Schwartz, Olivier Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development Comptes Rendus Biologies Placenta Interferons IFITMs Syncytiotrophoblast Cell–cell fusion |
| title | Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development |
| title_full | Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development |
| title_fullStr | Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development |
| title_full_unstemmed | Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development |
| title_short | Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development |
| title_sort | pregnancy complications and interferon induced transmembrane proteins ifitm balancing antiviral immunity and placental development |
| topic | Placenta Interferons IFITMs Syncytiotrophoblast Cell–cell fusion |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.54/ |
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