Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

Abstract Background The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. In a collaborative study by the Collaborative Study Group for the Micron...

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Bibliographic Details
Main Authors: Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita, Makoto Hayashi
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Genes and Environment
Subjects:
Micronucleus assay
Liver
Formalin-fixed tissue
Collagenase
Hepatocyte
Online Access:http://link.springer.com/article/10.1186/s41021-019-0128-5

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