Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol
Cannabidiol (CBD) is a non-intoxicating compound extracted from <i>Cannabis sativa</i>, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreo...
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MDPI AG
2021-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1269 |
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| author | Gabriela P. Silote Michelle C. Gatto Amanda Eskelund Francisco S. Guimarães Gregers Wegener Sâmia R. L. Joca |
| author_facet | Gabriela P. Silote Michelle C. Gatto Amanda Eskelund Francisco S. Guimarães Gregers Wegener Sâmia R. L. Joca |
| author_sort | Gabriela P. Silote |
| collection | DOAJ |
| description | Cannabidiol (CBD) is a non-intoxicating compound extracted from <i>Cannabis sativa</i>, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD’s behavioral response to rodents exposed to tests predictive of antidepressant effects. |
| first_indexed | 2024-03-10T03:20:43Z |
| format | Article |
| id | doaj.art-c187f292a4ac4f7289a45d8bee5f88e7 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:20:43Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-c187f292a4ac4f7289a45d8bee5f88e72023-11-23T10:03:21ZengMDPI AGPharmaceuticals1424-82472021-12-011412126910.3390/ph14121269Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of CannabidiolGabriela P. Silote0Michelle C. Gatto1Amanda Eskelund2Francisco S. Guimarães3Gregers Wegener4Sâmia R. L. Joca5Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto 14040-903, SP, BrazilDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto 14040-903, SP, BrazilTranslational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, DenmarkDepartment of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, BrazilTranslational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, DenmarkDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto 14040-903, SP, BrazilCannabidiol (CBD) is a non-intoxicating compound extracted from <i>Cannabis sativa</i>, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD’s behavioral response to rodents exposed to tests predictive of antidepressant effects.https://www.mdpi.com/1424-8247/14/12/1269cannabidiolS-ketaminesexmice strainFlinders Sensitive Line ratsFlinders Resistant Lines rats |
| spellingShingle | Gabriela P. Silote Michelle C. Gatto Amanda Eskelund Francisco S. Guimarães Gregers Wegener Sâmia R. L. Joca Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol Pharmaceuticals cannabidiol S-ketamine sex mice strain Flinders Sensitive Line rats Flinders Resistant Lines rats |
| title | Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol |
| title_full | Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol |
| title_fullStr | Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol |
| title_full_unstemmed | Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol |
| title_short | Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol |
| title_sort | strain sex and time dependent antidepressant like effects of cannabidiol |
| topic | cannabidiol S-ketamine sex mice strain Flinders Sensitive Line rats Flinders Resistant Lines rats |
| url | https://www.mdpi.com/1424-8247/14/12/1269 |
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