CD4+ T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques

CD4+ T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques

MazF, an endoribonuclease encoded by Escherichia coli, specifically cleaves the ACA (adenine–cytosine–adenine) sequence of single-stranded RNAs. Conditional expression of MazF under the control of the HIV-1 LTR promoter rendered CD4+ T cells resistant to HIV-1 replication without affecting cell grow...

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Bibliographic Details
Main Authors: Naoki Saito, Hideto Chono, Hiroaki Shibata, Naohide Ageyama, Yasuhiro Yasutomi, Junichi Mineno
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gene therapy
HIV-1
MazF
primate model
rhesus macaque
retroviral vector
SHIV
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303080

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