Identification of a Selective PDE4B Inhibitor From Bryophyllum pinnatum by Target Fishing Study and In Vitro Evaluation of Quercetin 3-O-α-L-Arabinopyranosyl-(1→2)-O-α-L-Rhamnopyranoside

Identification of a Selective PDE4B Inhibitor From Bryophyllum pinnatum by Target Fishing Study and In Vitro Evaluation of Quercetin 3-O-α-L-Arabinopyranosyl-(1→2)-O-α-L-Rhamnopyranoside

Natural products are considered an important source of bioactive compounds especially in biodiversity-rich countries like Brazil. The identification of potential targets is crucial to the development of drugs from natural sources. In this context, in silico methodologies, such as inverse virtual scr...

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Bibliographic Details
Main Authors: Estela M. G. Lourenço, Júlia M. Fernandes, Vinícius de F. Carvalho, Raphael Grougnet, Marco A. Martins, Alessandro K. Jordão, Silvana M. Zucolotto, Euzébio G. Barbosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
Bryophyllum pinnatum
natural products
PDE4
Flavonoid
inverse virtual screening
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01582/full

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