Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review
Objectives. This umbrella review aimed to consolidate the best available evidence regarding the clinical efficacy of platelet derivatives in the treatment of periodontal defects associated with periodontitis and in the management of mucogingival deformities. Materials and Methods. The “umbrella revi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2023/1099013 |
| _version_ | 1797783613894295552 |
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| author | Carlos M. Ardila María Pertuz Annie Marcela Vivares-Builes |
| author_facet | Carlos M. Ardila María Pertuz Annie Marcela Vivares-Builes |
| author_sort | Carlos M. Ardila |
| collection | DOAJ |
| description | Objectives. This umbrella review aimed to consolidate the best available evidence regarding the clinical efficacy of platelet derivatives in the treatment of periodontal defects associated with periodontitis and in the management of mucogingival deformities. Materials and Methods. The “umbrella review” strategy was used to identify systematic reviews and meta-analyses. The search was performed without language restrictions and updated at the end of February 2023. The PubMed and Scopus databases, together with gray literature, were included in the search. Results. The search yielded 412 studies. Subsequently, 12 articles were selected for further examination based on relevance. Finally, eight systematic reviews and meta-analyses were assessed. Regarding intrabony defects, in terms of clinical attachment level (CAL) gain, platelet-rich fibrin (PRF) was observed to lead to a statistically significant attachment gain compared to surgical therapy alone. PRF was also found to show greater CAL gain compared to platelet-rich plasma (PRP) and other biomaterials. The parameter probing depth decreased significantly when PRF was used compared to surgical therapy alone (P<0.05). Similar results were seen when leukocyte- and platelet-rich fibrin (L-PRF) was applied. In terms of radiographic bone fill, both PRF and PRP showed significantly greater bone fill compared to surgical therapy. Regarding the results of periodontal plastic surgery, PRF favored a slight root coverage compared to the coronally displaced flap. This result depended on the number of PRF and L-PRF membranes used, but Emdogain or connective tissue graft produced better results regardless. However, an improvement in the healing of periodontal tissues was reported. Conclusions. Therapies with platelet derivatives applied to intrabony defects provided superior regenerative results compared to monotherapies, except in the case of root coverage. |
| first_indexed | 2024-03-13T00:28:23Z |
| format | Article |
| id | doaj.art-c188af9e5042429195fdd274c8baf616 |
| institution | Directory Open Access Journal |
| issn | 1687-8736 |
| language | English |
| last_indexed | 2024-03-13T00:28:23Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj.art-c188af9e5042429195fdd274c8baf6162023-07-11T00:00:01ZengHindawi LimitedInternational Journal of Dentistry1687-87362023-01-01202310.1155/2023/1099013Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella ReviewCarlos M. Ardila0María Pertuz1Annie Marcela Vivares-Builes2Biomedical Stomatology Research GroupFundación Universitaria Visión de Las AméricasFundación Universitaria Visión de Las AméricasObjectives. This umbrella review aimed to consolidate the best available evidence regarding the clinical efficacy of platelet derivatives in the treatment of periodontal defects associated with periodontitis and in the management of mucogingival deformities. Materials and Methods. The “umbrella review” strategy was used to identify systematic reviews and meta-analyses. The search was performed without language restrictions and updated at the end of February 2023. The PubMed and Scopus databases, together with gray literature, were included in the search. Results. The search yielded 412 studies. Subsequently, 12 articles were selected for further examination based on relevance. Finally, eight systematic reviews and meta-analyses were assessed. Regarding intrabony defects, in terms of clinical attachment level (CAL) gain, platelet-rich fibrin (PRF) was observed to lead to a statistically significant attachment gain compared to surgical therapy alone. PRF was also found to show greater CAL gain compared to platelet-rich plasma (PRP) and other biomaterials. The parameter probing depth decreased significantly when PRF was used compared to surgical therapy alone (P<0.05). Similar results were seen when leukocyte- and platelet-rich fibrin (L-PRF) was applied. In terms of radiographic bone fill, both PRF and PRP showed significantly greater bone fill compared to surgical therapy. Regarding the results of periodontal plastic surgery, PRF favored a slight root coverage compared to the coronally displaced flap. This result depended on the number of PRF and L-PRF membranes used, but Emdogain or connective tissue graft produced better results regardless. However, an improvement in the healing of periodontal tissues was reported. Conclusions. Therapies with platelet derivatives applied to intrabony defects provided superior regenerative results compared to monotherapies, except in the case of root coverage.http://dx.doi.org/10.1155/2023/1099013 |
| spellingShingle | Carlos M. Ardila María Pertuz Annie Marcela Vivares-Builes Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review International Journal of Dentistry |
| title | Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review |
| title_full | Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review |
| title_fullStr | Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review |
| title_full_unstemmed | Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review |
| title_short | Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review |
| title_sort | clinical efficacy of platelet derivatives in periodontal tissue regeneration an umbrella review |
| url | http://dx.doi.org/10.1155/2023/1099013 |
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