Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
Avian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic loss to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.1031480/full |
| _version_ | 1798015059838894080 |
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| author | Xueyang Chen Xueyang Chen Xingming Wang Yuxin Yang Chun Fang Jing Liu Xiongyan Liang Yuying Yang |
| author_facet | Xueyang Chen Xueyang Chen Xingming Wang Yuxin Yang Chun Fang Jing Liu Xiongyan Liang Yuying Yang |
| author_sort | Xueyang Chen |
| collection | DOAJ |
| description | Avian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic loss to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In this study, A20 overexpression and shRNA interference recombinant adenoviruses were constructed and inoculated into chicken embryos, and ALV-A (rHB2015012) was inoculated into 1-day-old chicks. Analysis of body weight, organ index, detoxification, antibody production, organ toxin load, and Pathological observation revealed that A20 overexpression could enhance ALV-A pathogenicity. This study lays the foundation for subsequent exploration of the A20-mediated tumorigenic mechanism of ALV-A. |
| first_indexed | 2024-04-11T15:27:15Z |
| format | Article |
| id | doaj.art-c189318d77e34e32b03890965cba692b |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-11T15:27:15Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-c189318d77e34e32b03890965cba692b2022-12-22T04:16:13ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-11-01910.3389/fvets.2022.10314801031480Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infectionXueyang Chen0Xueyang Chen1Xingming Wang2Yuxin Yang3Chun Fang4Jing Liu5Xiongyan Liang6Yuying Yang7College of Animal Science, Yangtze University, Jingzhou, ChinaCollege of Agriculture, Yangtze University, Jingzhou, ChinaCollege of Animal Science, Yangtze University, Jingzhou, ChinaCollege of Animal Science, Yangtze University, Jingzhou, ChinaCollege of Animal Science, Yangtze University, Jingzhou, ChinaCollege of Animal Science, Yangtze University, Jingzhou, ChinaCollege of Animal Science, Yangtze University, Jingzhou, ChinaCollege of Animal Science, Yangtze University, Jingzhou, ChinaAvian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic loss to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In this study, A20 overexpression and shRNA interference recombinant adenoviruses were constructed and inoculated into chicken embryos, and ALV-A (rHB2015012) was inoculated into 1-day-old chicks. Analysis of body weight, organ index, detoxification, antibody production, organ toxin load, and Pathological observation revealed that A20 overexpression could enhance ALV-A pathogenicity. This study lays the foundation for subsequent exploration of the A20-mediated tumorigenic mechanism of ALV-A.https://www.frontiersin.org/articles/10.3389/fvets.2022.1031480/fullALV-AchickenA20recombinant adenoviruspathogenic |
| spellingShingle | Xueyang Chen Xueyang Chen Xingming Wang Yuxin Yang Chun Fang Jing Liu Xiongyan Liang Yuying Yang Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection Frontiers in Veterinary Science ALV-A chicken A20 recombinant adenovirus pathogenic |
| title | Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection |
| title_full | Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection |
| title_fullStr | Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection |
| title_full_unstemmed | Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection |
| title_short | Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection |
| title_sort | enhanced pathogenicity by up regulation of a20 after avian leukemia subgroup a virus infection |
| topic | ALV-A chicken A20 recombinant adenovirus pathogenic |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.1031480/full |
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