Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume
Background: The rapid maturation of the fetal brain renders the fetus susceptible to prenatal environmental signals. Prenatal maternal sleep quality is known to have important health implications for newborns including risk for preterm birth, however, the effect on the fetal brain is poorly understo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929322001177 |
| _version_ | 1811199567338668032 |
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| author | Melissa Nevarez-Brewster Catherine H. Demers Alexandra Mejia Mercedes Hoeflich Haase Maria M. Bagonis Sun Hyung Kim John H. Gilmore M. Camille Hoffman Martin A. Styner Benjamin L. Hankin Elysia Poggi Davis |
| author_facet | Melissa Nevarez-Brewster Catherine H. Demers Alexandra Mejia Mercedes Hoeflich Haase Maria M. Bagonis Sun Hyung Kim John H. Gilmore M. Camille Hoffman Martin A. Styner Benjamin L. Hankin Elysia Poggi Davis |
| author_sort | Melissa Nevarez-Brewster |
| collection | DOAJ |
| description | Background: The rapid maturation of the fetal brain renders the fetus susceptible to prenatal environmental signals. Prenatal maternal sleep quality is known to have important health implications for newborns including risk for preterm birth, however, the effect on the fetal brain is poorly understood. Method: Participants included 94 pregnant participants and their newborns (53% female). Pregnant participants (Mage = 30; SDage= 5.29) reported on sleep quality three times throughout pregnancy. Newborn hippocampal and amygdala volumes were assessed using structural magnetic resonance imaging. Multilevel modeling was used to test the associations between trajectories of prenatal maternal sleep quality and newborn hippocampal and amygdala volume. Results: The overall trajectory of prenatal maternal sleep quality was associated with hippocampal volume (left: b = 0.00003, p = 0.013; right: b = 0.00003, p = .008). Follow up analyses assessing timing of exposure indicate that poor sleep quality early in pregnancy was associated with larger hippocampal volume bilaterally (e.g., late gestation left: b = 0.002, p = 0.24; right: b = 0.004, p = .11). Prenatal sleep quality was not associated with amygdala volume. Conclusion: These findings highlight the implications of poor prenatal maternal sleep quality and its role in contributing to newborn hippocampal development. |
| first_indexed | 2024-04-12T01:49:47Z |
| format | Article |
| id | doaj.art-c189fad7e7164a2fb7488d1fc6b32422 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-12T01:49:47Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-c189fad7e7164a2fb7488d1fc6b324222022-12-22T03:52:58ZengElsevierDevelopmental Cognitive Neuroscience1878-92932022-12-0158101174Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volumeMelissa Nevarez-Brewster0Catherine H. Demers1Alexandra Mejia2Mercedes Hoeflich Haase3Maria M. Bagonis4Sun Hyung Kim5John H. Gilmore6M. Camille Hoffman7Martin A. Styner8Benjamin L. Hankin9Elysia Poggi Davis10University of Denver, Department of Psychology, United States; Correspondence to: Department of Psychology, University of Denver, 2155 S Race St., Denver, CO 80208, United States.University of Denver, Department of Psychology, United States; University of Colorado Anschutz Medical Campus, Department of Psychiatry, United StatesUniversity of Denver, Department of Psychology, United StatesUniversity of North Carolina – Chapel Hill, Department of Psychiatry, United StatesUniversity of North Carolina – Chapel Hill, Department of Psychiatry, United StatesUniversity of North Carolina – Chapel Hill, Department of Psychiatry, United StatesUniversity of North Carolina – Chapel Hill, Department of Psychiatry, United StatesUniversity of Colorado Anschutz Medical Campus, Department of Psychiatry, United States; University of Colorado Denver School of Medicine, Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, United StatesUniversity of North Carolina – Chapel Hill, Department of Psychiatry, United States; University of North Carolina – Chapel Hill, Department of Computer Science, United StatesUniversity of Illinois at Urbana-Champaign, Department of Psychology, United StatesUniversity of Denver, Department of Psychology, United States; University of California, Irvine, Department of Pediatrics, United StatesBackground: The rapid maturation of the fetal brain renders the fetus susceptible to prenatal environmental signals. Prenatal maternal sleep quality is known to have important health implications for newborns including risk for preterm birth, however, the effect on the fetal brain is poorly understood. Method: Participants included 94 pregnant participants and their newborns (53% female). Pregnant participants (Mage = 30; SDage= 5.29) reported on sleep quality three times throughout pregnancy. Newborn hippocampal and amygdala volumes were assessed using structural magnetic resonance imaging. Multilevel modeling was used to test the associations between trajectories of prenatal maternal sleep quality and newborn hippocampal and amygdala volume. Results: The overall trajectory of prenatal maternal sleep quality was associated with hippocampal volume (left: b = 0.00003, p = 0.013; right: b = 0.00003, p = .008). Follow up analyses assessing timing of exposure indicate that poor sleep quality early in pregnancy was associated with larger hippocampal volume bilaterally (e.g., late gestation left: b = 0.002, p = 0.24; right: b = 0.004, p = .11). Prenatal sleep quality was not associated with amygdala volume. Conclusion: These findings highlight the implications of poor prenatal maternal sleep quality and its role in contributing to newborn hippocampal development.http://www.sciencedirect.com/science/article/pii/S1878929322001177PregnancySleepNewborn neurodevelopmentAmygdalaHippocampusMRI |
| spellingShingle | Melissa Nevarez-Brewster Catherine H. Demers Alexandra Mejia Mercedes Hoeflich Haase Maria M. Bagonis Sun Hyung Kim John H. Gilmore M. Camille Hoffman Martin A. Styner Benjamin L. Hankin Elysia Poggi Davis Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume Developmental Cognitive Neuroscience Pregnancy Sleep Newborn neurodevelopment Amygdala Hippocampus MRI |
| title | Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume |
| title_full | Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume |
| title_fullStr | Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume |
| title_full_unstemmed | Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume |
| title_short | Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume |
| title_sort | longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume |
| topic | Pregnancy Sleep Newborn neurodevelopment Amygdala Hippocampus MRI |
| url | http://www.sciencedirect.com/science/article/pii/S1878929322001177 |
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