Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats
ABSTRACT: The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats. Single administration of imipramine (30 mg/kg, i.p.) attenuated 8-OH-DPAT-induced hypothermia. This effect of...
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| Format: | Article |
| Language: | English |
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Elsevier
2003-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319325745 |
| _version_ | 1819229529638436864 |
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| author | Yoshihisa Kitamura Hiroaki Araki Kazuhiko Shibata Yutaka Gomita Yoshiro Yoshiro |
| author_facet | Yoshihisa Kitamura Hiroaki Araki Kazuhiko Shibata Yutaka Gomita Yoshiro Yoshiro |
| author_sort | Yoshihisa Kitamura |
| collection | DOAJ |
| description | ABSTRACT: The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats. Single administration of imipramine (30 mg/kg, i.p.) attenuated 8-OH-DPAT-induced hypothermia. This effect of imipramine was blocked by the 5-HT2A-receptor antagonist ketanserin. 8-OH-DPAT-induced hypothermia was not altered 24 h after repeated administration of imipramine (1 – 10 mg/kg per day) for 14 days. However, 8-OH-DPAT-induced hypothermia was significantly enhanced in repeated imipramine (10 mg/kg per day)-treated rats that received 8-OH-DPAT plus imipramine 24 h after the final imipramine administration for 14 days. The 5-HT2A-receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ((±)-DOI) attenuated the 8-OH-DPAT-induced hypothermia in drug naive rats. The inhibitory effect of (±)-DOI (0.3 mg/kg, s.c.) on 8-OH-DPAT-induced hypothermia was attenuated by repeated administration of imipramine (10 mg/kg per day) for 14 days. These findings suggest that enhancement of the 5-HT1A receptors by repeated administration of imipramine may be due to reduction of the inhibitory effects from the 5-HT2A receptors to the 5-HT1A receptors. |
| first_indexed | 2024-12-23T11:14:38Z |
| format | Article |
| id | doaj.art-c18b0d8008d64a0b92275e9cce873b90 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-23T11:14:38Z |
| publishDate | 2003-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-c18b0d8008d64a0b92275e9cce873b902022-12-21T17:49:15ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-01933259264Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in RatsYoshihisa Kitamura0Hiroaki Araki1Kazuhiko Shibata2Yutaka Gomita3Yoshiro Yoshiro4Division of Pharmacy, and Division of Meidicine, Misasa Medical Center, Okayama University Medical School, 827 Yamada, Misasa-cho, Tohaku-gun, Tottori 682-0192, JapanDivision of Hospital Pharmacy, Ehime University Hospital, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDivision of Meidicine, Misasa Medical Center, Okayama University Medical School, 827 Yamada, Misasa-cho, Tohaku-gun, Tottori 682-0192, JapanABSTRACT: The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats. Single administration of imipramine (30 mg/kg, i.p.) attenuated 8-OH-DPAT-induced hypothermia. This effect of imipramine was blocked by the 5-HT2A-receptor antagonist ketanserin. 8-OH-DPAT-induced hypothermia was not altered 24 h after repeated administration of imipramine (1 – 10 mg/kg per day) for 14 days. However, 8-OH-DPAT-induced hypothermia was significantly enhanced in repeated imipramine (10 mg/kg per day)-treated rats that received 8-OH-DPAT plus imipramine 24 h after the final imipramine administration for 14 days. The 5-HT2A-receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ((±)-DOI) attenuated the 8-OH-DPAT-induced hypothermia in drug naive rats. The inhibitory effect of (±)-DOI (0.3 mg/kg, s.c.) on 8-OH-DPAT-induced hypothermia was attenuated by repeated administration of imipramine (10 mg/kg per day) for 14 days. These findings suggest that enhancement of the 5-HT1A receptors by repeated administration of imipramine may be due to reduction of the inhibitory effects from the 5-HT2A receptors to the 5-HT1A receptors.http://www.sciencedirect.com/science/article/pii/S1347861319325745 |
| spellingShingle | Yoshihisa Kitamura Hiroaki Araki Kazuhiko Shibata Yutaka Gomita Yoshiro Yoshiro Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats Journal of Pharmacological Sciences |
| title | Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats |
| title_full | Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats |
| title_fullStr | Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats |
| title_full_unstemmed | Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats |
| title_short | Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats |
| title_sort | modulation of 8 oh dpat induced hypothermia by imipramine in rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319325745 |
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