HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways

HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways

Abstract Background Holliday junction recognition protein (HJURP) has been implicated in many cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by which HJURP promotes HCC cell proliferation remains unclear. Methods RT-qPCR and immunohistochemistry were used to dete...

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Bibliographic Details
Main Authors: Tianchi Chen, Hechen Huang, Yuan Zhou, Lei Geng, Tian Shen, Shengyong Yin, Lin Zhou, Shusen Zheng
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HJURP
Proliferation
p21
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-018-0866-4

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