RhoA Signaling in Immune Cell Response and Cardiac Disease
Chronic inflammation, the activation of immune cells and their cross-talk with cardiomyocytes in the pathogenesis and progression of heart diseases has long been overlooked. However, with the latest research developments, it is increasingly accepted that a vicious cycle exists where cardiomyocytes r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1681 |
| _version_ | 1797527484575514624 |
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| author | Lucia Sophie Kilian Derk Frank Ashraf Yusuf Rangrez |
| author_facet | Lucia Sophie Kilian Derk Frank Ashraf Yusuf Rangrez |
| author_sort | Lucia Sophie Kilian |
| collection | DOAJ |
| description | Chronic inflammation, the activation of immune cells and their cross-talk with cardiomyocytes in the pathogenesis and progression of heart diseases has long been overlooked. However, with the latest research developments, it is increasingly accepted that a vicious cycle exists where cardiomyocytes release cardiocrine signaling molecules that spiral down to immune cell activation and chronic state of low-level inflammation. For example, cardiocrine molecules released from injured or stressed cardiomyocytes can stimulate macrophages, dendritic cells, neutrophils and even T-cells, which then subsequently increase cardiac inflammation by co-stimulation and positive feedback loops. One of the key proteins involved in stress-mediated cardiomyocyte signal transduction is a small GTPase RhoA. Importantly, the regulation of RhoA activation is critical for effective immune cell response and is being considered as one of the potential therapeutic targets in many immune-cell-mediated inflammatory diseases. In this review we provide an update on the role of RhoA at the juncture of immune cell activation, inflammation and cardiac disease. |
| first_indexed | 2024-03-10T09:43:27Z |
| format | Article |
| id | doaj.art-c18b6d25edbb4cefa57ad2b7d5c64ef2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:27Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c18b6d25edbb4cefa57ad2b7d5c64ef22023-11-22T03:28:19ZengMDPI AGCells2073-44092021-07-01107168110.3390/cells10071681RhoA Signaling in Immune Cell Response and Cardiac DiseaseLucia Sophie Kilian0Derk Frank1Ashraf Yusuf Rangrez2Department of Internal Medicine III, Cardiology, Angiology, Intensive Care, University Medical Center Kiel, 24105 Kiel, GermanyDepartment of Internal Medicine III, Cardiology, Angiology, Intensive Care, University Medical Center Kiel, 24105 Kiel, GermanyDepartment of Internal Medicine III, Cardiology, Angiology, Intensive Care, University Medical Center Kiel, 24105 Kiel, GermanyChronic inflammation, the activation of immune cells and their cross-talk with cardiomyocytes in the pathogenesis and progression of heart diseases has long been overlooked. However, with the latest research developments, it is increasingly accepted that a vicious cycle exists where cardiomyocytes release cardiocrine signaling molecules that spiral down to immune cell activation and chronic state of low-level inflammation. For example, cardiocrine molecules released from injured or stressed cardiomyocytes can stimulate macrophages, dendritic cells, neutrophils and even T-cells, which then subsequently increase cardiac inflammation by co-stimulation and positive feedback loops. One of the key proteins involved in stress-mediated cardiomyocyte signal transduction is a small GTPase RhoA. Importantly, the regulation of RhoA activation is critical for effective immune cell response and is being considered as one of the potential therapeutic targets in many immune-cell-mediated inflammatory diseases. In this review we provide an update on the role of RhoA at the juncture of immune cell activation, inflammation and cardiac disease.https://www.mdpi.com/2073-4409/10/7/1681RhoAcardiac inflammationimmune cellscardiocrine signalingcardiac diseases |
| spellingShingle | Lucia Sophie Kilian Derk Frank Ashraf Yusuf Rangrez RhoA Signaling in Immune Cell Response and Cardiac Disease Cells RhoA cardiac inflammation immune cells cardiocrine signaling cardiac diseases |
| title | RhoA Signaling in Immune Cell Response and Cardiac Disease |
| title_full | RhoA Signaling in Immune Cell Response and Cardiac Disease |
| title_fullStr | RhoA Signaling in Immune Cell Response and Cardiac Disease |
| title_full_unstemmed | RhoA Signaling in Immune Cell Response and Cardiac Disease |
| title_short | RhoA Signaling in Immune Cell Response and Cardiac Disease |
| title_sort | rhoa signaling in immune cell response and cardiac disease |
| topic | RhoA cardiac inflammation immune cells cardiocrine signaling cardiac diseases |
| url | https://www.mdpi.com/2073-4409/10/7/1681 |
| work_keys_str_mv | AT luciasophiekilian rhoasignalinginimmunecellresponseandcardiacdisease AT derkfrank rhoasignalinginimmunecellresponseandcardiacdisease AT ashrafyusufrangrez rhoasignalinginimmunecellresponseandcardiacdisease |