Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway.

Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway.

BACKGROUND:Leptin is an adipocyte-derived hormone that plays a critical role in energy homeostasis and lipid metabolism. Overnutrition-associated obesity is known to be accompanied by hyperleptinemia. However, the physiological actions of leptin in the metabolic responses to high-fat diet (HFD) inta...

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Bibliographic Details
Main Authors: Lei Jiang, Qiong Wang, Yue Yu, Feng Zhao, Ping Huang, Rong Zeng, Robert Z Qi, Wenjun Li, Yong Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2731220?pdf=render

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