Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD
Abstract Background Chronic kidney disease (CKD) manifested as reduced GFR and/or albuminuria, has been known to accelerate arterial stiffness and early vascular aging (EVA). Diabetes, hypertension, and glomerular disorders are the leading causes of CKD and renal failure. The question which etiology...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Artery Research |
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| Online Access: | https://doi.org/10.1007/s44200-023-00034-4 |
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| author | Ori Lencovsky Avital Angel-Korman Erick Glasswine Rotem Tal-Ben Ishay Mor Amital Olga Kukuy Adi Leiba |
| author_facet | Ori Lencovsky Avital Angel-Korman Erick Glasswine Rotem Tal-Ben Ishay Mor Amital Olga Kukuy Adi Leiba |
| author_sort | Ori Lencovsky |
| collection | DOAJ |
| description | Abstract Background Chronic kidney disease (CKD) manifested as reduced GFR and/or albuminuria, has been known to accelerate arterial stiffness and early vascular aging (EVA). Diabetes, hypertension, and glomerular disorders are the leading causes of CKD and renal failure. The question which etiology contributes more to this vascular phenomenon-hypertensive and diabetic CKD or CKD secondary to immune-mediated glomerulonephritis—remained unclear. Objective To compare pulse wave velocity (PWV), a marker of arterial stiffness, between CKD patients of different etiologies: hypertensive and diabetic nephrosclerosis. vs. CKD secondary to glomerular disorders. Methods Clinical data were collected on 56 patients followed at the Nephrology and Hypertension Institute in Samson Assuta Ashdod University Hospital. All patients had at least one visit at our Nephrology clinics prior to recruitment. All patients with a glomerular disorder had a clinical-pathological diagnosis based on a recent kidney biopsy. Pulse wave velocity (PWV) was measured using a validated Sphygmocor XCEL® device. Univariate and multivariate analyses were performed to compare PWV between hypertensive/diabetic CKD and CKD secondary to glomerular disorders. Results PWV was significantly higher in the hypertensive/diabetic CKD group, compared to the CKD-GN group, with an average of. 12.2 m/s vs 8.3 m/s, respectively (p < 0.001). In a multivariate linear regression model, having CKD secondary to glomerulonephritis was associated with a significantly lower PWV (B = − 3.262, p < 0.001), compared with CKD secondary to hypertension and diabetes, with adjustment of age, creatinine, and comorbidities. Conclusion CKD Patients secondary to glomerulonephritis, have lower PWV when compared to CKD patients with diabetes and/or hypertension, even after adjusting for age, renal function, and the presence of comorbidities. It is intriguing to further study the possible protective role of immunosuppression on the arterial properties of CKD patients. |
| first_indexed | 2024-03-12T01:41:51Z |
| format | Article |
| id | doaj.art-c194c069d2fa4643a54f65913edd7db0 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-03-12T01:41:51Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-c194c069d2fa4643a54f65913edd7db02023-09-10T11:09:16ZengBMCArtery Research1876-44012023-06-01293737810.1007/s44200-023-00034-4Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKDOri Lencovsky0Avital Angel-Korman1Erick Glasswine2Rotem Tal-Ben Ishay3Mor Amital4Olga Kukuy5Adi Leiba6Faculty of Health Sciences, Joyce and Irving Goldman Medical School at Ben Gurion, University of the NegevFaculty of Health Sciences, Joyce and Irving Goldman Medical School at Ben Gurion, University of the NegevFaculty of Health Sciences, Joyce and Irving Goldman Medical School at Ben Gurion, University of the NegevFaculty of Health Sciences, Joyce and Irving Goldman Medical School at Ben Gurion, University of the NegevSheba Medical Center, Tel HashomerSheba Medical Center, Tel HashomerFaculty of Health Sciences, Joyce and Irving Goldman Medical School at Ben Gurion, University of the NegevAbstract Background Chronic kidney disease (CKD) manifested as reduced GFR and/or albuminuria, has been known to accelerate arterial stiffness and early vascular aging (EVA). Diabetes, hypertension, and glomerular disorders are the leading causes of CKD and renal failure. The question which etiology contributes more to this vascular phenomenon-hypertensive and diabetic CKD or CKD secondary to immune-mediated glomerulonephritis—remained unclear. Objective To compare pulse wave velocity (PWV), a marker of arterial stiffness, between CKD patients of different etiologies: hypertensive and diabetic nephrosclerosis. vs. CKD secondary to glomerular disorders. Methods Clinical data were collected on 56 patients followed at the Nephrology and Hypertension Institute in Samson Assuta Ashdod University Hospital. All patients had at least one visit at our Nephrology clinics prior to recruitment. All patients with a glomerular disorder had a clinical-pathological diagnosis based on a recent kidney biopsy. Pulse wave velocity (PWV) was measured using a validated Sphygmocor XCEL® device. Univariate and multivariate analyses were performed to compare PWV between hypertensive/diabetic CKD and CKD secondary to glomerular disorders. Results PWV was significantly higher in the hypertensive/diabetic CKD group, compared to the CKD-GN group, with an average of. 12.2 m/s vs 8.3 m/s, respectively (p < 0.001). In a multivariate linear regression model, having CKD secondary to glomerulonephritis was associated with a significantly lower PWV (B = − 3.262, p < 0.001), compared with CKD secondary to hypertension and diabetes, with adjustment of age, creatinine, and comorbidities. Conclusion CKD Patients secondary to glomerulonephritis, have lower PWV when compared to CKD patients with diabetes and/or hypertension, even after adjusting for age, renal function, and the presence of comorbidities. It is intriguing to further study the possible protective role of immunosuppression on the arterial properties of CKD patients.https://doi.org/10.1007/s44200-023-00034-4CKDGlomerulonephritisPulse wave velocityAortic stiffnessInflammation |
| spellingShingle | Ori Lencovsky Avital Angel-Korman Erick Glasswine Rotem Tal-Ben Ishay Mor Amital Olga Kukuy Adi Leiba Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD Artery Research CKD Glomerulonephritis Pulse wave velocity Aortic stiffness Inflammation |
| title | Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD |
| title_full | Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD |
| title_fullStr | Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD |
| title_full_unstemmed | Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD |
| title_short | Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD |
| title_sort | patients with ckd secondary to glomerular disorders have lower arterial stiffness as compared to hypertensive and diabetic ckd |
| topic | CKD Glomerulonephritis Pulse wave velocity Aortic stiffness Inflammation |
| url | https://doi.org/10.1007/s44200-023-00034-4 |
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