A study on the antibiotic resistance of Shigella
Background The hospital morbidity caused by Shigella or dysen- tery ranges between 0.3 to 2.9%. Irrational use of antibiotics causes a persistent diarrhea and may lead to drug resistance. Objectives With various kinds of antibiotics available in Indone- sia at the moment, this study aimed to anticip...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/798 |
| _version_ | 1828389536106807296 |
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| author | Pramita G Dwipoerwantoro Sri P Pulungsih Nuraini I Susanti Hartaniah Sadikin Agus Firmansyah |
| author_facet | Pramita G Dwipoerwantoro Sri P Pulungsih Nuraini I Susanti Hartaniah Sadikin Agus Firmansyah |
| author_sort | Pramita G Dwipoerwantoro |
| collection | DOAJ |
| description | Background The hospital morbidity caused by Shigella or dysen-
tery ranges between 0.3 to 2.9%. Irrational use of antibiotics causes
a persistent diarrhea and may lead to drug resistance.
Objectives With various kinds of antibiotics available in Indone-
sia at the moment, this study aimed to anticipate the kinds of anti-
biotics appropriate for shigellosis and to evaluate the clinical spec-
trum of dysentery in children in Indonesia.
Method The study involved 50 children diagnosed with dysentery
or dysentery-like syndrome, aged 1 to 12 years, who came to four
different hospitals in Jakarta, from November 2001 to April 2002.
Parents were asked for their consent. Interviewers recorded de-
tails of the children’s history of illness and the physical examina-
tions. Stool culture and resistance tests were done.
Results Fifty dysentery cases, comprising 30 males and 20 fe-
males, 98% aged from 1 to 5 years, came to the four hospitals
during the study period. Only 24 cases had positive Shigella cul-
tures, of which 87% were Shigella flexneri and 17% were Shigella
sonnei. The clinical manifestations of shigellosis were bloody stools
(83%), mucus in the stool (75%), and watery diarrhea (96%). Fe-
ver and tenesmus were absent in 67% and 92% of subjects, re-
spectively. Almost 87% of shigellosis cases were resistant to
cotrimoxazole; all were sensitive to colistin and most were sensi-
tive to nalidixic acid.
Conclusion This data suggests that colistin and nalidixic acid are
drugs of choice for dysentery syndrome. The clinical manifesta-
tion of dysentery is not always accompanied by bloody stools but
mostly incorporates watery diarrhea and mucus in the stool |
| first_indexed | 2024-12-10T06:30:44Z |
| format | Article |
| id | doaj.art-c195447e27214ba996d2aa1770cf6c2b |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-10T06:30:44Z |
| publishDate | 2016-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-c195447e27214ba996d2aa1770cf6c2b2022-12-22T01:59:05ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-01452495410.14238/pi45.2.2005.49-54661A study on the antibiotic resistance of ShigellaPramita G DwipoerwantoroSri P PulungsihNuraini I SusantiHartaniah SadikinAgus FirmansyahBackground The hospital morbidity caused by Shigella or dysen- tery ranges between 0.3 to 2.9%. Irrational use of antibiotics causes a persistent diarrhea and may lead to drug resistance. Objectives With various kinds of antibiotics available in Indone- sia at the moment, this study aimed to anticipate the kinds of anti- biotics appropriate for shigellosis and to evaluate the clinical spec- trum of dysentery in children in Indonesia. Method The study involved 50 children diagnosed with dysentery or dysentery-like syndrome, aged 1 to 12 years, who came to four different hospitals in Jakarta, from November 2001 to April 2002. Parents were asked for their consent. Interviewers recorded de- tails of the children’s history of illness and the physical examina- tions. Stool culture and resistance tests were done. Results Fifty dysentery cases, comprising 30 males and 20 fe- males, 98% aged from 1 to 5 years, came to the four hospitals during the study period. Only 24 cases had positive Shigella cul- tures, of which 87% were Shigella flexneri and 17% were Shigella sonnei. The clinical manifestations of shigellosis were bloody stools (83%), mucus in the stool (75%), and watery diarrhea (96%). Fe- ver and tenesmus were absent in 67% and 92% of subjects, re- spectively. Almost 87% of shigellosis cases were resistant to cotrimoxazole; all were sensitive to colistin and most were sensi- tive to nalidixic acid. Conclusion This data suggests that colistin and nalidixic acid are drugs of choice for dysentery syndrome. The clinical manifesta- tion of dysentery is not always accompanied by bloody stools but mostly incorporates watery diarrhea and mucus in the stoolhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/798dysenteryshigellosischildrenantibioticsantibiotic resistanceantibiotic sensitivity |
| spellingShingle | Pramita G Dwipoerwantoro Sri P Pulungsih Nuraini I Susanti Hartaniah Sadikin Agus Firmansyah A study on the antibiotic resistance of Shigella Paediatrica Indonesiana dysentery shigellosis children antibiotics antibiotic resistance antibiotic sensitivity |
| title | A study on the antibiotic resistance of Shigella |
| title_full | A study on the antibiotic resistance of Shigella |
| title_fullStr | A study on the antibiotic resistance of Shigella |
| title_full_unstemmed | A study on the antibiotic resistance of Shigella |
| title_short | A study on the antibiotic resistance of Shigella |
| title_sort | study on the antibiotic resistance of shigella |
| topic | dysentery shigellosis children antibiotics antibiotic resistance antibiotic sensitivity |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/798 |
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