The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer
Bladder cancer (BC) is one of the most common types of cancer worldwide, with significant differences in survival depending on the degree of muscle and surrounding tissue invasion. For this reason, the timely detection and monitoring of the disease are important. Surveillance cystoscopy is an invasi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/4/2178 |
| _version_ | 1797298033988206592 |
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| author | Maria Iyali Torres-Bustamante Jorge Raul Vazquez-Urrutia Fabiola Solorzano-Ibarra Pablo Cesar Ortiz-Lazareno |
| author_facet | Maria Iyali Torres-Bustamante Jorge Raul Vazquez-Urrutia Fabiola Solorzano-Ibarra Pablo Cesar Ortiz-Lazareno |
| author_sort | Maria Iyali Torres-Bustamante |
| collection | DOAJ |
| description | Bladder cancer (BC) is one of the most common types of cancer worldwide, with significant differences in survival depending on the degree of muscle and surrounding tissue invasion. For this reason, the timely detection and monitoring of the disease are important. Surveillance cystoscopy is an invasive, costly, and uncomfortable procedure to monitor BC, raising the need for new, less invasive alternatives. In this scenario, microRNAs (miRNAs) represent attractive prognostic tools given their role as gene regulators in different biological processes, tissue expression, and their ease of evaluation in liquid samples. In cancer, miRNA expression is dynamically modified depending on the tumor type and cancer staging, making them potential biomarkers. This review describes the most recent studies in the last five years exploring the utility of miRNA-based strategies to monitor progression, stratify, and predict relevant clinical outcomes of bladder cancer. Several studies have shown that multimarker miRNA models can better predict overall survival, recurrence, and progression in BC patients than traditional strategies, especially when combining miRNA expression with clinicopathological variables. Future studies should focus on validating their use in different cohorts and liquid samples. |
| first_indexed | 2024-03-07T22:29:02Z |
| format | Article |
| id | doaj.art-c198ff48d3d643e397f5a1b83e54878d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:29:02Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c198ff48d3d643e397f5a1b83e54878d2024-02-23T15:20:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254217810.3390/ijms25042178The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder CancerMaria Iyali Torres-Bustamante0Jorge Raul Vazquez-Urrutia1Fabiola Solorzano-Ibarra2Pablo Cesar Ortiz-Lazareno3Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, MexicoDepartment of Medicine, The Pennsylvania State University College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USAInstituto de Investigación en Enfermedades Crónico Degenerativas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, MexicoDivisión de Inmunología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, MexicoBladder cancer (BC) is one of the most common types of cancer worldwide, with significant differences in survival depending on the degree of muscle and surrounding tissue invasion. For this reason, the timely detection and monitoring of the disease are important. Surveillance cystoscopy is an invasive, costly, and uncomfortable procedure to monitor BC, raising the need for new, less invasive alternatives. In this scenario, microRNAs (miRNAs) represent attractive prognostic tools given their role as gene regulators in different biological processes, tissue expression, and their ease of evaluation in liquid samples. In cancer, miRNA expression is dynamically modified depending on the tumor type and cancer staging, making them potential biomarkers. This review describes the most recent studies in the last five years exploring the utility of miRNA-based strategies to monitor progression, stratify, and predict relevant clinical outcomes of bladder cancer. Several studies have shown that multimarker miRNA models can better predict overall survival, recurrence, and progression in BC patients than traditional strategies, especially when combining miRNA expression with clinicopathological variables. Future studies should focus on validating their use in different cohorts and liquid samples.https://www.mdpi.com/1422-0067/25/4/2178miRNAsbladder cancerbiomarkersprognosis |
| spellingShingle | Maria Iyali Torres-Bustamante Jorge Raul Vazquez-Urrutia Fabiola Solorzano-Ibarra Pablo Cesar Ortiz-Lazareno The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer International Journal of Molecular Sciences miRNAs bladder cancer biomarkers prognosis |
| title | The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer |
| title_full | The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer |
| title_fullStr | The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer |
| title_full_unstemmed | The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer |
| title_short | The Role of miRNAs to Detect Progression, Stratify, and Predict Relevant Clinical Outcomes in Bladder Cancer |
| title_sort | role of mirnas to detect progression stratify and predict relevant clinical outcomes in bladder cancer |
| topic | miRNAs bladder cancer biomarkers prognosis |
| url | https://www.mdpi.com/1422-0067/25/4/2178 |
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