A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes

A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes

Kallmann syndrome is the result of innate genetic defects in the fibroblast growth factor (FGF) regulated signaling network causing diminished signal transduction. One of the rare mutations associated with the syndrome alters the Sprouty (Spry)4 protein by converting the serine at position 241 into...

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Bibliographic Details
Main Authors: Astrid Stütz, Anna Z. M. Kamptner, Hedwig Sutterlüty
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
Spry4
Sprouty protein
Kallmann syndrome
FGFR1
FGF-mediated signaling
MAPK pathway
Online Access:https://www.mdpi.com/1422-0067/22/4/2145

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