Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals
Laser-induced breakdown spectroscopy (LIBS) of pharmaceutical drugs that contain paracetamol was investigated in air and argon atmospheres. The characteristic neutral and ionic spectral lines of various elements and molecular signatures of CN violet and C<sub>2</sub> Swan band systems we...
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MDPI AG
2019-07-01
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| Online Access: | https://www.mdpi.com/2218-2004/7/3/71 |
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| author | Pravin Kumar Tiwari Nilesh Kumar Rai Rohit Kumar Christian G. Parigger Awadhesh Kumar Rai |
| author_facet | Pravin Kumar Tiwari Nilesh Kumar Rai Rohit Kumar Christian G. Parigger Awadhesh Kumar Rai |
| author_sort | Pravin Kumar Tiwari |
| collection | DOAJ |
| description | Laser-induced breakdown spectroscopy (LIBS) of pharmaceutical drugs that contain paracetamol was investigated in air and argon atmospheres. The characteristic neutral and ionic spectral lines of various elements and molecular signatures of CN violet and C<sub>2</sub> Swan band systems were observed. The relative hardness of all drug samples was measured as well. Principal component analysis, a multivariate method, was applied in the data analysis for demarcation purposes of the drug samples. The CN violet and C<sub>2</sub> Swan spectral radiances were investigated for evaluation of a possible correlation of the chemical and molecular structures of the pharmaceuticals. Complementary Raman and Fourier-transform-infrared spectroscopies were used to record the molecular spectra of the drug samples. The application of the above techniques for drug screening are important for the identification and mitigation of drugs that contain additives that may cause adverse side-effects. |
| first_indexed | 2024-12-20T11:44:52Z |
| format | Article |
| id | doaj.art-c19bae76e9714347ab32d093d2b52d9d |
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| issn | 2218-2004 |
| language | English |
| last_indexed | 2024-12-20T11:44:52Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-c19bae76e9714347ab32d093d2b52d9d2022-12-21T19:41:53ZengMDPI AGAtoms2218-20042019-07-01737110.3390/atoms7030071atoms7030071Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected PharmaceuticalsPravin Kumar Tiwari0Nilesh Kumar Rai1Rohit Kumar2Christian G. Parigger3Awadhesh Kumar Rai4Institute for Plasma Research, Gandhinagar, Gujarat 382428, IndiaCMP Degree College, Department of Physics, University of Allahabad, Pragyagraj 211002, IndiaCMP Degree College, Department of Physics, University of Allahabad, Pragyagraj 211002, IndiaPhysics and Astronomy Department, University of Tennessee, University of Tennessee Space Institute, Center for Laser Applications, 411 B.H. Goethert Parkway, Tullahoma, TN 37388-9700, USALaser Spectroscopy Research Laboratory, Department of Physics, University of Allahabad, Prayagraj 211002, IndiaLaser-induced breakdown spectroscopy (LIBS) of pharmaceutical drugs that contain paracetamol was investigated in air and argon atmospheres. The characteristic neutral and ionic spectral lines of various elements and molecular signatures of CN violet and C<sub>2</sub> Swan band systems were observed. The relative hardness of all drug samples was measured as well. Principal component analysis, a multivariate method, was applied in the data analysis for demarcation purposes of the drug samples. The CN violet and C<sub>2</sub> Swan spectral radiances were investigated for evaluation of a possible correlation of the chemical and molecular structures of the pharmaceuticals. Complementary Raman and Fourier-transform-infrared spectroscopies were used to record the molecular spectra of the drug samples. The application of the above techniques for drug screening are important for the identification and mitigation of drugs that contain additives that may cause adverse side-effects.https://www.mdpi.com/2218-2004/7/3/71paracetamollaser-induced breakdown spectroscopycyanidecarbon swan bandsprincipal component analysisRaman spectroscopyFourier-transform-infrared spectroscopy |
| spellingShingle | Pravin Kumar Tiwari Nilesh Kumar Rai Rohit Kumar Christian G. Parigger Awadhesh Kumar Rai Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals Atoms paracetamol laser-induced breakdown spectroscopy cyanide carbon swan bands principal component analysis Raman spectroscopy Fourier-transform-infrared spectroscopy |
| title | Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals |
| title_full | Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals |
| title_fullStr | Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals |
| title_full_unstemmed | Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals |
| title_short | Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals |
| title_sort | atomic and molecular laser induced breakdown spectroscopy of selected pharmaceuticals |
| topic | paracetamol laser-induced breakdown spectroscopy cyanide carbon swan bands principal component analysis Raman spectroscopy Fourier-transform-infrared spectroscopy |
| url | https://www.mdpi.com/2218-2004/7/3/71 |
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