Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females
Evidence suggests an increasing apnea–hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (...
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| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/1/79 |
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| author | Christopher Seifen Johannes Pordzik Katharina Bahr Lisa Große-Brüggemann Katharina Ludwig Berit Hackenberg Christoph Matthias Perikles Simon Haralampos Gouveris |
| author_facet | Christopher Seifen Johannes Pordzik Katharina Bahr Lisa Große-Brüggemann Katharina Ludwig Berit Hackenberg Christoph Matthias Perikles Simon Haralampos Gouveris |
| author_sort | Christopher Seifen |
| collection | DOAJ |
| description | Evidence suggests an increasing apnea–hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (OSA)-related comorbidities and body mass index (BMI) into account. Therefore, we retrospectively analyzed 186 first-time polysomnographic (PSG) recordings and medical files of all patients presented to a tertiary university sleep center during a 1-year period. Six groups were formed based on age (over vs. under 55 years) and gender: PSG-related parameters (AHI, apnea-index, and hypopnea-index) were significantly higher in the older mixed-gender cohort (<i>p</i> = 0.0001, <i>p</i> = 0.0011, and <i>p</i> = 0.0015, respectively), and the older female cohort (<i>p</i> = 0.0005, <i>p</i> = 0.0027, and <i>p</i> = 0.001, respectively). Within the older male cohort, the AHI and apnea-index were significantly higher (<i>p</i> = 0.0067, and <i>p</i> = 0.0135, respectively). Inter-group comparison of the BMI showed no significant difference in any subpopulation. Within the older male cohort there were significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders (<i>p</i> < 0.0001, <i>p</i> = 0.001, <i>p</i> = 0.0181, and <i>p</i> = 0.0454, respectively). Contrarily, within the female subpopulation there were no significant differences for the aforementioned comorbidities. In conclusion, all investigated sleep PSG-parameters increased among the older subpopulations. We suggest that Osa severity may increase with age due to the increasing accumulation of comorbidities in males, but not in females. |
| first_indexed | 2024-03-09T12:03:04Z |
| format | Article |
| id | doaj.art-c19dc223d2b247d081787dd4eed6aaab |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T12:03:04Z |
| publishDate | 2022-12-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-c19dc223d2b247d081787dd4eed6aaab2023-11-30T23:01:51ZengMDPI AGJournal of Personalized Medicine2075-44262022-12-011317910.3390/jpm13010079Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in FemalesChristopher Seifen0Johannes Pordzik1Katharina Bahr2Lisa Große-Brüggemann3Katharina Ludwig4Berit Hackenberg5Christoph Matthias6Perikles Simon7Haralampos Gouveris8Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanyDepartment of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg University, 55099 Mainz, GermanySleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, GermanyEvidence suggests an increasing apnea–hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (OSA)-related comorbidities and body mass index (BMI) into account. Therefore, we retrospectively analyzed 186 first-time polysomnographic (PSG) recordings and medical files of all patients presented to a tertiary university sleep center during a 1-year period. Six groups were formed based on age (over vs. under 55 years) and gender: PSG-related parameters (AHI, apnea-index, and hypopnea-index) were significantly higher in the older mixed-gender cohort (<i>p</i> = 0.0001, <i>p</i> = 0.0011, and <i>p</i> = 0.0015, respectively), and the older female cohort (<i>p</i> = 0.0005, <i>p</i> = 0.0027, and <i>p</i> = 0.001, respectively). Within the older male cohort, the AHI and apnea-index were significantly higher (<i>p</i> = 0.0067, and <i>p</i> = 0.0135, respectively). Inter-group comparison of the BMI showed no significant difference in any subpopulation. Within the older male cohort there were significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders (<i>p</i> < 0.0001, <i>p</i> = 0.001, <i>p</i> = 0.0181, and <i>p</i> = 0.0454, respectively). Contrarily, within the female subpopulation there were no significant differences for the aforementioned comorbidities. In conclusion, all investigated sleep PSG-parameters increased among the older subpopulations. We suggest that Osa severity may increase with age due to the increasing accumulation of comorbidities in males, but not in females.https://www.mdpi.com/2075-4426/13/1/79obstructive sleep apneaapnea–hypopnea indexapnea indexhypopnea indexageobstructive sleep apnea and age |
| spellingShingle | Christopher Seifen Johannes Pordzik Katharina Bahr Lisa Große-Brüggemann Katharina Ludwig Berit Hackenberg Christoph Matthias Perikles Simon Haralampos Gouveris Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females Journal of Personalized Medicine obstructive sleep apnea apnea–hypopnea index apnea index hypopnea index age obstructive sleep apnea and age |
| title | Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females |
| title_full | Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females |
| title_fullStr | Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females |
| title_full_unstemmed | Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females |
| title_short | Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females |
| title_sort | accumulating comorbidities may promote increasing severity of obstructive sleep apnea with aging in males but not in females |
| topic | obstructive sleep apnea apnea–hypopnea index apnea index hypopnea index age obstructive sleep apnea and age |
| url | https://www.mdpi.com/2075-4426/13/1/79 |
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