Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report
Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-06-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735417722225 |
| _version_ | 1818924969819635712 |
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| author | Juyoung Ryu MS, KMD Kangwook Lee BS, KMD Changmug Joe PhD, MD JongCheon Joo PhD, KMD Namhun Lee PhD, KMD Hwa-Seung Yoo PhD, KMD |
| author_facet | Juyoung Ryu MS, KMD Kangwook Lee BS, KMD Changmug Joe PhD, MD JongCheon Joo PhD, KMD Namhun Lee PhD, KMD Hwa-Seung Yoo PhD, KMD |
| author_sort | Juyoung Ryu MS, KMD |
| collection | DOAJ |
| description | Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy. However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. He was suffering from fatigue, dyspepsia, epigastralgia, and jaundice. Hyperthermia combined with chemotherapy was administered 32 times over a period of 4 months. The patient experienced no critical complications, and the patient’s condition improved, with the carbohydrate antigen 19-9 (CA 19-9) and the total bilirubin levels being relatively lowered. In addition, the computed tomography scan showed that the cholangiocarcinoma had not progressed. In conclusion, this case report suggests radiofrequency hyperthermia combined with chemotherapy may be a promising treatment option for patients with unresectable cholangiocarcinoma. |
| first_indexed | 2024-12-20T02:33:47Z |
| format | Article |
| id | doaj.art-c19fb9debf044f56a10331d0d5fa780c |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-20T02:33:47Z |
| publishDate | 2018-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-c19fb9debf044f56a10331d0d5fa780c2022-12-21T19:56:31ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2018-06-011710.1177/1534735417722225Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case ReportJuyoung Ryu MS, KMD0Kangwook Lee BS, KMD1Changmug Joe PhD, MD2JongCheon Joo PhD, KMD3Namhun Lee PhD, KMD4Hwa-Seung Yoo PhD, KMD5Cheonan Korean Medical Hospital, Daejeon University, Cheonan, KoreaCheonan Korean Medical Hospital, Daejeon University, Cheonan, KoreaCheonan Korean Medical Hospital, Daejeon University, Cheonan, KoreaJeonju Korean Medicine Hospital, Wonkwang University, Jeonju, KoreaCheonan Korean Medical Hospital, Daejeon University, Cheonan, KoreaDunsan Korean Medicine Hospital, Daejeon University, Daejeon, KoreaHyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy. However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. He was suffering from fatigue, dyspepsia, epigastralgia, and jaundice. Hyperthermia combined with chemotherapy was administered 32 times over a period of 4 months. The patient experienced no critical complications, and the patient’s condition improved, with the carbohydrate antigen 19-9 (CA 19-9) and the total bilirubin levels being relatively lowered. In addition, the computed tomography scan showed that the cholangiocarcinoma had not progressed. In conclusion, this case report suggests radiofrequency hyperthermia combined with chemotherapy may be a promising treatment option for patients with unresectable cholangiocarcinoma.https://doi.org/10.1177/1534735417722225 |
| spellingShingle | Juyoung Ryu MS, KMD Kangwook Lee BS, KMD Changmug Joe PhD, MD JongCheon Joo PhD, KMD Namhun Lee PhD, KMD Hwa-Seung Yoo PhD, KMD Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report Integrative Cancer Therapies |
| title | Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report |
| title_full | Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report |
| title_fullStr | Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report |
| title_full_unstemmed | Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report |
| title_short | Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report |
| title_sort | patient with unresectable cholangiocarcinoma treated with radiofrequency hyperthermia in combination with chemotherapy a case report |
| url | https://doi.org/10.1177/1534735417722225 |
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