Longitudinal profiles of the fecal metabolome during the first 2 years of life
Abstract During the first 2 years of life, the infant gut microbiome is rapidly developing, and gut bacteria may impact host health through the production of metabolites that can have systemic effects. Thus, the fecal metabolome represents a functional readout of gut bacteria. Despite the important...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28862-z |
| _version_ | 1811171720160083968 |
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| author | Elizabeth A. Holzhausen Natalie Shen Bridget Chalifour ViLinh Tran Zhenjiang Li Jeremy A. Sarnat Howard H. Chang Dean P. Jones Michael I. Goran Donghai Liang Tanya L. Alderete |
| author_facet | Elizabeth A. Holzhausen Natalie Shen Bridget Chalifour ViLinh Tran Zhenjiang Li Jeremy A. Sarnat Howard H. Chang Dean P. Jones Michael I. Goran Donghai Liang Tanya L. Alderete |
| author_sort | Elizabeth A. Holzhausen |
| collection | DOAJ |
| description | Abstract During the first 2 years of life, the infant gut microbiome is rapidly developing, and gut bacteria may impact host health through the production of metabolites that can have systemic effects. Thus, the fecal metabolome represents a functional readout of gut bacteria. Despite the important role that fecal metabolites may play in infant health, the development of the infant fecal metabolome has not yet been thoroughly characterized using frequent, repeated sampling during the first 2 years of life. Here, we described the development of the fecal metabolome in a cohort of 101 Latino infants with data collected at 1-, 6-, 12-, 18-, and 24-months of age. We showed that the fecal metabolome is highly conserved across time and highly personalized, with metabolic profiles being largely driven by intra-individual variability. Finally, we also identified several novel metabolites and metabolic pathways that changed significantly with infant age, such as valerobetaine and amino acid metabolism, among others. |
| first_indexed | 2024-04-10T17:19:48Z |
| format | Article |
| id | doaj.art-c1a147d4df544f02b94276482c85bd03 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T17:19:48Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c1a147d4df544f02b94276482c85bd032023-02-05T12:12:05ZengNature PortfolioScientific Reports2045-23222023-02-0113111210.1038/s41598-023-28862-zLongitudinal profiles of the fecal metabolome during the first 2 years of lifeElizabeth A. Holzhausen0Natalie Shen1Bridget Chalifour2ViLinh Tran3Zhenjiang Li4Jeremy A. Sarnat5Howard H. Chang6Dean P. Jones7Michael I. Goran8Donghai Liang9Tanya L. Alderete10Department of Integrative Physiology, University of Colorado – BoulderRollins School of Public Health, Emory UniversityDepartment of Integrative Physiology, University of Colorado – BoulderSchool of Medicine, Emory UniversityRollins School of Public Health, Emory UniversityRollins School of Public Health, Emory UniversityRollins School of Public Health, Emory UniversitySchool of Medicine, Emory UniversityChildren’s Hospital Los AngelesRollins School of Public Health, Emory UniversityDepartment of Integrative Physiology, University of Colorado – BoulderAbstract During the first 2 years of life, the infant gut microbiome is rapidly developing, and gut bacteria may impact host health through the production of metabolites that can have systemic effects. Thus, the fecal metabolome represents a functional readout of gut bacteria. Despite the important role that fecal metabolites may play in infant health, the development of the infant fecal metabolome has not yet been thoroughly characterized using frequent, repeated sampling during the first 2 years of life. Here, we described the development of the fecal metabolome in a cohort of 101 Latino infants with data collected at 1-, 6-, 12-, 18-, and 24-months of age. We showed that the fecal metabolome is highly conserved across time and highly personalized, with metabolic profiles being largely driven by intra-individual variability. Finally, we also identified several novel metabolites and metabolic pathways that changed significantly with infant age, such as valerobetaine and amino acid metabolism, among others.https://doi.org/10.1038/s41598-023-28862-z |
| spellingShingle | Elizabeth A. Holzhausen Natalie Shen Bridget Chalifour ViLinh Tran Zhenjiang Li Jeremy A. Sarnat Howard H. Chang Dean P. Jones Michael I. Goran Donghai Liang Tanya L. Alderete Longitudinal profiles of the fecal metabolome during the first 2 years of life Scientific Reports |
| title | Longitudinal profiles of the fecal metabolome during the first 2 years of life |
| title_full | Longitudinal profiles of the fecal metabolome during the first 2 years of life |
| title_fullStr | Longitudinal profiles of the fecal metabolome during the first 2 years of life |
| title_full_unstemmed | Longitudinal profiles of the fecal metabolome during the first 2 years of life |
| title_short | Longitudinal profiles of the fecal metabolome during the first 2 years of life |
| title_sort | longitudinal profiles of the fecal metabolome during the first 2 years of life |
| url | https://doi.org/10.1038/s41598-023-28862-z |
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