Genotype-phenotype correlation of deletions and duplications of 4p: case reports and literature review

Genotype-phenotype correlation of deletions and duplications of 4p: case reports and literature review

Structural rearrangements of chromosome 4p gives rise to a group of rare genomic disorders that mainly result in two different clinical entities: Wolf-Hirschhorn syndrome (WHS) and partial 4p trisomy. The severity of the phenotype depends on the size of the deletion or locus duplication. Here, we pr...

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Bibliographic Details
Main Authors: Xuan Zhang, Hongjuan Lu, Hanran Yang, Yichen Ji, Huixin Liu, Wenjian Liu, Jiayi Li, Zhixian Yang, Wei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Genetics
Subjects:
chromosome 4p
terminal 4p deletion
wolf-Hirschhorn syndrome
partial duplication 4p
4p trisomy
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1174314/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1174314/full

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