Bile acid receptors and signaling crosstalk in the liver, gut and brain
Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient absorption, and they play roles in glucose, lipid, and energy metabolism and in gut microbiome and metabolic homeostasis. Bile acids mediate crosstalk between the liver and gut through bactericidal mo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-09-01
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| Series: | Liver Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568421000453 |
| _version_ | 1818648945023254528 |
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| author | Jessica M. Ferrell John Y.L. Chiang |
| author_facet | Jessica M. Ferrell John Y.L. Chiang |
| author_sort | Jessica M. Ferrell |
| collection | DOAJ |
| description | Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient absorption, and they play roles in glucose, lipid, and energy metabolism and in gut microbiome and metabolic homeostasis. Bile acids mediate crosstalk between the liver and gut through bactericidal modulation of the gut microbiome, while gut microbes influence the composition of the circulating bile acid pool. Recent research indicates bile acids may also be important mediators of neurological disease by acting as peripheral signaling molecules that activate bile acid receptors in the blood-brain barrier and in the brain itself. This review highlights the role of bile acids in maintaining liver and gut microbe homeostasis, as well as their function as mediators of cellular signaling in the liver-gut-brain axis. |
| first_indexed | 2024-12-17T01:26:29Z |
| format | Article |
| id | doaj.art-c1a4bf34f6254b05b6bc3c1c2266e196 |
| institution | Directory Open Access Journal |
| issn | 2542-5684 |
| language | English |
| last_indexed | 2024-12-17T01:26:29Z |
| publishDate | 2021-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj.art-c1a4bf34f6254b05b6bc3c1c2266e1962022-12-21T22:08:41ZengKeAi Communications Co., Ltd.Liver Research2542-56842021-09-0153105118Bile acid receptors and signaling crosstalk in the liver, gut and brainJessica M. Ferrell0John Y.L. Chiang1Corresponding author.; Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USAIntegrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USABile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient absorption, and they play roles in glucose, lipid, and energy metabolism and in gut microbiome and metabolic homeostasis. Bile acids mediate crosstalk between the liver and gut through bactericidal modulation of the gut microbiome, while gut microbes influence the composition of the circulating bile acid pool. Recent research indicates bile acids may also be important mediators of neurological disease by acting as peripheral signaling molecules that activate bile acid receptors in the blood-brain barrier and in the brain itself. This review highlights the role of bile acids in maintaining liver and gut microbe homeostasis, as well as their function as mediators of cellular signaling in the liver-gut-brain axis.http://www.sciencedirect.com/science/article/pii/S2542568421000453Bile acid metabolismFarnesoid X receptor (FXR)Gut-brain axisMicrobiomeNeurodegenerative diseaseTakeda G protein-coupled receptor (TGR5) |
| spellingShingle | Jessica M. Ferrell John Y.L. Chiang Bile acid receptors and signaling crosstalk in the liver, gut and brain Liver Research Bile acid metabolism Farnesoid X receptor (FXR) Gut-brain axis Microbiome Neurodegenerative disease Takeda G protein-coupled receptor (TGR5) |
| title | Bile acid receptors and signaling crosstalk in the liver, gut and brain |
| title_full | Bile acid receptors and signaling crosstalk in the liver, gut and brain |
| title_fullStr | Bile acid receptors and signaling crosstalk in the liver, gut and brain |
| title_full_unstemmed | Bile acid receptors and signaling crosstalk in the liver, gut and brain |
| title_short | Bile acid receptors and signaling crosstalk in the liver, gut and brain |
| title_sort | bile acid receptors and signaling crosstalk in the liver gut and brain |
| topic | Bile acid metabolism Farnesoid X receptor (FXR) Gut-brain axis Microbiome Neurodegenerative disease Takeda G protein-coupled receptor (TGR5) |
| url | http://www.sciencedirect.com/science/article/pii/S2542568421000453 |
| work_keys_str_mv | AT jessicamferrell bileacidreceptorsandsignalingcrosstalkinthelivergutandbrain AT johnylchiang bileacidreceptorsandsignalingcrosstalkinthelivergutandbrain |