Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion

Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion

T-cell exhaustion refers to a state of T-cell dysfunction commonly observed in chronic infections and cancer. Immune checkpoint molecules blockading using PD-1 and TIM-3 antibodies have shown promising results in reversing exhaustion, but this approach has several limitations. The treatment of T-cel...

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Bibliographic Details
Main Authors: Fei Li, Yahong Wang, Dandan Chen, Yunjie Du
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
T-cell exhaustion
nanoparticle
immune checkpoint blockade
tumor microenvironment
T cell metabolism
Online Access:https://www.mdpi.com/1422-0067/25/3/1396

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