Cognitive impairments in Hashimoto's encephalopathy: a case-control study.
BACKGROUND/AIMS: Hashimoto's encephalopathy is considered as a treatable dementia, but it is often misdiagnosed. We investigated cognitive impairment and the MRI pathology of Hashimoto's encephalopathy patients. METHODS: The study comprised eight patients with Hashimoto's encephalopat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3568150?pdf=render |
| _version_ | 1811266548182024192 |
|---|---|
| author | Jianhong Wang Jun Zhang Lan Xu Yunbo Shi Xunyi Wu Qihao Guo |
| author_facet | Jianhong Wang Jun Zhang Lan Xu Yunbo Shi Xunyi Wu Qihao Guo |
| author_sort | Jianhong Wang |
| collection | DOAJ |
| description | BACKGROUND/AIMS: Hashimoto's encephalopathy is considered as a treatable dementia, but it is often misdiagnosed. We investigated cognitive impairment and the MRI pathology of Hashimoto's encephalopathy patients. METHODS: The study comprised eight patients with Hashimoto's encephalopathy, 16 patients with mild Alzheimer's disease and 24 healthy subjects. A neuropsychological battery included assessments of memory, language, attention, executive function and visuospatial ability. Cranial MRI was obtained from all Hashimoto's encephalopathy patients. RESULTS: Hashimoto's encephalopathy and mild Alzheimer's disease showed cognitive impairments in episodic memory, attention, executive function and visuospatial ability, but naming ability was unaffected in Hashimoto's encephalopathy. The MRI of Hashimoto's encephalopathy showed leukoencephalopathy-like type or limbic encephalitis-like type; the lesions did not affect the temporal cortex which plays a role in naming ability. CONCLUSION: Except that the naming ability was retained, the impairments in cognitive functions for the Hashimoto's encephalopathy patients were similar to those of Alzheimer's disease patients. These results were consistent with the MRI findings. |
| first_indexed | 2024-04-12T20:44:04Z |
| format | Article |
| id | doaj.art-c1a927e05b0645208103c1880a4e274b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T20:44:04Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c1a927e05b0645208103c1880a4e274b2022-12-22T03:17:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5575810.1371/journal.pone.0055758Cognitive impairments in Hashimoto's encephalopathy: a case-control study.Jianhong WangJun ZhangLan XuYunbo ShiXunyi WuQihao GuoBACKGROUND/AIMS: Hashimoto's encephalopathy is considered as a treatable dementia, but it is often misdiagnosed. We investigated cognitive impairment and the MRI pathology of Hashimoto's encephalopathy patients. METHODS: The study comprised eight patients with Hashimoto's encephalopathy, 16 patients with mild Alzheimer's disease and 24 healthy subjects. A neuropsychological battery included assessments of memory, language, attention, executive function and visuospatial ability. Cranial MRI was obtained from all Hashimoto's encephalopathy patients. RESULTS: Hashimoto's encephalopathy and mild Alzheimer's disease showed cognitive impairments in episodic memory, attention, executive function and visuospatial ability, but naming ability was unaffected in Hashimoto's encephalopathy. The MRI of Hashimoto's encephalopathy showed leukoencephalopathy-like type or limbic encephalitis-like type; the lesions did not affect the temporal cortex which plays a role in naming ability. CONCLUSION: Except that the naming ability was retained, the impairments in cognitive functions for the Hashimoto's encephalopathy patients were similar to those of Alzheimer's disease patients. These results were consistent with the MRI findings.http://europepmc.org/articles/PMC3568150?pdf=render |
| spellingShingle | Jianhong Wang Jun Zhang Lan Xu Yunbo Shi Xunyi Wu Qihao Guo Cognitive impairments in Hashimoto's encephalopathy: a case-control study. PLoS ONE |
| title | Cognitive impairments in Hashimoto's encephalopathy: a case-control study. |
| title_full | Cognitive impairments in Hashimoto's encephalopathy: a case-control study. |
| title_fullStr | Cognitive impairments in Hashimoto's encephalopathy: a case-control study. |
| title_full_unstemmed | Cognitive impairments in Hashimoto's encephalopathy: a case-control study. |
| title_short | Cognitive impairments in Hashimoto's encephalopathy: a case-control study. |
| title_sort | cognitive impairments in hashimoto s encephalopathy a case control study |
| url | http://europepmc.org/articles/PMC3568150?pdf=render |
| work_keys_str_mv | AT jianhongwang cognitiveimpairmentsinhashimotosencephalopathyacasecontrolstudy AT junzhang cognitiveimpairmentsinhashimotosencephalopathyacasecontrolstudy AT lanxu cognitiveimpairmentsinhashimotosencephalopathyacasecontrolstudy AT yunboshi cognitiveimpairmentsinhashimotosencephalopathyacasecontrolstudy AT xunyiwu cognitiveimpairmentsinhashimotosencephalopathyacasecontrolstudy AT qihaoguo cognitiveimpairmentsinhashimotosencephalopathyacasecontrolstudy |